Clean Preparation of Quinolin-2-yl Substituted Ureas in Water

被引：85

作者：

Xie, Long-Yong ^{[1
]}

Peng, Sha ^{[1
]}

Liu, Fang ^{[1
]}

Liu, Yan-Fang ^{[1
]}

Sun, Meng ^{[2
]}

Tang, Zi-Long ^{[2
]}

Jiang, Si ^{[3
]}

Cao, Zhong ^{[3
]}

He, Wei-Min ^{[1
]}

机构：

[1] Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China

[2] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China

[3] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Hunan, Peoples R China

来源：

ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2019年 / 7卷 / 07期

关键词：

In water; Quinoline N-oxides; Atom economy; Reusability; Green chemistry; HETEROAROMATIC N-OXIDES; ONE-POT SYNTHESIS; MEDIATED SULFONYLATION; BASE-FREE; METAL; AMINATION; ACTIVATION; MILD; BOND; ALKYNES;

D O I：

10.1021/acssuschemeng.9b00200

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An environmentally-friendly method for the clean preparation of various quinolin-2-yl substituted ureas in water under mild and toxic reagent-, base-, and organic solvent-free conditions was established. In the large-scale synthesis, the products could be rapidly collected via simple filtration and washing with ethanol. The usage of readily available raw materials, 100% atom economy, high yield, and excellent regioselectivity enhanced the practicability of this protocol.

引用

页码：7193 / 7199

页数：13

共 77 条

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