Cancer Stem Cells in the Mechanism of Metal Carcinogenesis

被引：7

作者：

Wang, Lei ^{[1
]}

Chen, Fei ^{[2
]}

Zhang, Zhuo ^{[1
]}

Chen, Gang ^{[3
]}

Luo, Jia ^{[3
]}

Shi, Xianglin ^{[1
]}

机构：

[1] Univ Kentucky, Grad Ctr Toxicol, Coll Med, Lexington, KY 40536 USA

[2] Wayne State Univ, Dept Pharmaceut Sci, Eugene Applebaum Coll Pharm & Hlth Sci, Detroit, MI USA

[3] Univ Kentucky, Dept Internal Med, Coll Med, Lexington, KY 40536 USA

来源：

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY | 2012年 / 31卷 / 03期

基金：

美国国家卫生研究院;

关键词：

metal; carcinogenesis; reactive oxygen species; cancer stem cell; angiogenesis; OXIDATIVE DNA-DAMAGE; ALDEHYDE DEHYDROGENASE 1; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; MEDIATES RADIATION-RESISTANCE; ENDOTHELIAL GROWTH-FACTOR; ACUTE MYELOID-LEUKEMIA; ANGIOGENESIS IN-VITRO; DRINKING-WATER; LUNG-CANCER; TUMOR ANGIOGENESIS;

D O I：

10.1615/JEnvironPatholToxicolOncol.v31.i3.60

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Environmental metal carcinogenesis is a major public health concern. The mechanism underlying metal-induced carcinogenesis remains unclear. The concept of cancer stem cell recently has drawn considerable attention. Various studies indicate that the generation of cancer stem cells might contribute to the overall mechanism of development of metal-induced cancer. It is believed that oxidative stress and abnormal signaling caused by metals lead to the enrichment of cancer stem cells and eventually initiate cancer. In addition, metal-induced angiogenesis may also contribute to the generation of cancer stem cells. Studies using animal models further suggest that metals could induce the production of cancer stem cells and thus cause the development of cancer. This review summarizes recent studies of oxidative stress and cancer stem cells in relation to the mechanism of metal carcinogenesis.

引用

页码：245 / 263

页数：19

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