Role of Bibersteinia trehalosi, respiratory syncytial virus, and parainfluenza-3 virus in bighorn sheep pneumonia

被引：27

作者：

Dassanayake, Rohana P. ^{[1
]}

Shanthalingam, Sudarvili ^{[1
]}

Subramaniam, Renuka ^{[1
]}

Herndon, Caroline N. ^{[1
]}

Bavananthasivam, Jegarubee ^{[1
]}

Haldorson, Gary J. ^{[1
,2
]}

Foreyt, William J. ^{[1
]}

Evermann, James F. ^{[1
,2
]}

Herrmann-Hoesing, Lynn M. ^{[3
]}

Knowles, Donald P. ^{[1
,3
]}

Srikumaran, Subramaniam ^{[1
]}

机构：

[1] Washington State Univ, Dept Vet Microbiol & Pathol, Pullman, WA 99164 USA

[2] Washington State Univ, Washington Anim Dis Diagnost Lab, Pullman, WA 99164 USA

[3] Washington State Univ, USDA ARS, Anim Dis Res Unit, Pullman, WA 99164 USA

来源：

VETERINARY MICROBIOLOGY | 2013年 / 162卷 / 01期

关键词：

Bighorn sheep; Pneumonia; Bibersteinia trehalosi; Mannheimia haemolytica; Respiratory syncytial virus; Parainfluenza-3; virus; OVIS-CANADENSIS-CANADENSIS; PASTEURELLA-HAEMOLYTICA; MANNHEIMIA-HAEMOLYTICA; MYCOPLASMA-OVIPNEUMONIAE; DOMESTIC SHEEP; BOVINE HERPESVIRUS-1; DISEASE; INFECTION;

D O I：

10.1016/j.vetmic.2012.08.029

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pneumonic bighorn sheep (BHS) have been found to be culture- and/or sero-positive for Bibersteinia trehalosi, respiratory syncytial virus (RSV), and parainfluenza-3 virus (PI-3). The objective of this study was to determine whether these pathogens can cause fatal pneumonia in BHS. In the first study, two groups of four BHS each were intra-tracheally administered with leukotoxin-positive (Group I) or leukotoxin-negative (Group II) B. trehalosi. All four animals in Group I developed severe pneumonia, and two of them died within 3 days. The other two animals showed severe pneumonic lesions on euthanasia and necropsy. Animals in Group II neither died nor showed gross pneumonic lesions on necropsy, suggesting that leukotoxin-positive, but not leukotoxin-negative, B. trehalosi can cause fatal pneumonia in BHS. In the second study, two other groups of four BHS (Groups III and IV) were intra-nasally administered with a mixture of RSV and PI-3. Four days later, RSV/PI-3-inoculated Group IV and another group of four BHS (Group V, positive control) were intra-nasally administered with Mannheimia haemolytica, the pathogen that consistently causes fatal pneumonia in BHS. All four animals in group III developed pneumonia, but did not die during the study period. However all four animals in Group IV, and three animals in Group V developed severe pneumonia and died within two days of M. haemolytica inoculation. The fourth animal in Group V showed severe pneumonic lesions on euthanasia and necropsy. These findings suggest that RSV/PI-3 can cause non-fatal pneumonia, but are not necessary predisposing agents for M. haemolytica-caused pneumonia of BHS. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：166 / 172

页数：7