An efficient synthesis of optically active metabolites of platelet adhesion inhibitor OPC-29030 by lipase-catalyzed enantioselective transesterification

被引：16

作者：

Kitano, K ^{[1
]}

Matsubara, J ^{[1
]}

Ohtani, T ^{[1
]}

Otsubo, K ^{[1
]}

Kawano, Y ^{[1
]}

Morita, S ^{[1
]}

Uchida, M ^{[1
]}

机构：

[1] Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Tokushima 7710192, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(99)00946-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The optically active metabolites of (S)-3,4-dihydro-6-[3-(1-o-tolyl-2-imidazolyl)sulfinylpropoxy]-2(1H)-quinolinone (OPC-29030, 1), which is a new anti-platelet agent (platelet adhesion inhibitor), were effectively synthesized by the enzyme-catalyzed enantioselective transesterification of the racemic sulfinyl metabolites. The enzymes can recognize a stereogenic sulfur atom remote fi om the reaction site. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5235 / 5238

页数：4

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