An efficient synthesis of optically active metabolites of platelet adhesion inhibitor OPC-29030 by lipase-catalyzed enantioselective transesterification

被引：16
|
作者：
Kitano, K [1 ]
Matsubara, J [1 ]
Ohtani, T [1 ]
Otsubo, K [1 ]
Kawano, Y [1 ]
Morita, S [1 ]
Uchida, M [1 ]
机构：
[1] Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Tokushima 7710192, Japan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 28期
关键词：
D O I：
10.1016/S0040-4039(99)00946-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The optically active metabolites of (S)-3,4-dihydro-6-[3-(1-o-tolyl-2-imidazolyl)sulfinylpropoxy]-2(1H)-quinolinone (OPC-29030, 1), which is a new anti-platelet agent (platelet adhesion inhibitor), were effectively synthesized by the enzyme-catalyzed enantioselective transesterification of the racemic sulfinyl metabolites. The enzymes can recognize a stereogenic sulfur atom remote fi om the reaction site. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：5235 / 5238
页数：4
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