Breast cancer immunobiology driving immunotherapy: vaccines and immune checkpoint blockade

被引：10

作者：

Emens, Leisha A. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD 21231 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2012年 / 12卷 / 12期

关键词：

breast cancer immunity; breast cancer vaccine; clinical trials; immune checkpoint blockade; immune tolerance; immunotherapy; tumor microenvironment; GROUP-STUDY I-01; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; HER2/NEU PEPTIDE E75; I CLINICAL-TRIAL; METASTATIC BREAST; PHASE-I; DENDRITIC CELLS; EARLY-STAGE; PERIPHERAL-BLOOD;

D O I：

10.1586/ERA.12.147

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is immunogenic, and infiltrating immune cells in primary breast tumors convey important clinical prognostic and predictive information. Furthermore, the immune system is critically involved in clinical responses to some standard cancer therapies. Early breast cancer vaccine trials have established the safety and bioactivity of breast cancer immunotherapy, with hints of clinical activity. Novel strategies for modulating regulators of immunity, including regulatory T cells, myeloid-derived suppressor cells and immune checkpoint pathways (monoclonal antibodies specific for the cytotoxic T-lymphocyte antigen-4 or programmed death), are now available. In particular, immune checkpoint blockade has enormous therapeutic potential. Integrative breast cancer immunotherapies that strategically combine established breast cancer therapies with breast cancer vaccines, immune checkpoint blockade or both should result in durable clinical responses and increased cures.

引用

页码：1597 / 1611

页数：15

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