Looking for inspiration: new perspectives on respiratory rhythm

被引：629
作者：
Feldman, JL
Del Negro, CA
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA
[2] Coll William & Mary, Dept Appl Sci, Williamsburg, VA 23187 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 03期
关键词：
D O I：
10.1038/nrn1871
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent experiments in vivo and in vitro have advanced our understanding of the sites and mechanisms involved in mammalian respiratory rhythm generation. Here we evaluate and interpret the new evidence for two separate brainstem respiratory oscillators and for the essential role of emergent network properties in rhythm generation. Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing.
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页码：232 / 242
页数：11
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