Application of Hybrid Models to Blood Cell Production in the Bone Marrow

被引：13
作者：
Bessonov, N. [1 ,2 ]
Crauste, F. [1 ,3 ]
Fischer, S. [1 ,3 ]
Kurbatova, P. [1 ,3 ]
Volpert, V. [1 ,3 ]
机构：
[1] Univ Lyon 1, Inst Camille Jordan, CNRS, UMR 5208, F-69622 Villeurbanne, France
[2] Inst Mech Engn Problems, St Petersburg 199178, Russia
[3] INRIA Rhone Alpes, Team Project Dracula, Sophia Antipolis, France
来源：
MATHEMATICAL MODELLING OF NATURAL PHENOMENA | 2011年 / 6卷 / 07期
关键词：
hybrid models; erythropoiesis; regulatory mechanisms; SELF-RENEWAL; ERYTHROPOIESIS; DIFFERENTIATION; PROGENITORS; RELEVANCE;
D O I：
10.1051/mmnp/20116701
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.
引用
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页码：2 / 12
页数：11
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