Background: Single cerebral toxoplasmic lesions are rarely explored. Methods: Through magnetic resonance imaging, 10 lesions were analyzed regarding location, signal intensity, contrast enhancement, eccentric target, and meningeal uptake. Results: Five lesions were corticosubcortical and in the deep three (60%) had infratentorial locations. Iso- or hypointense signal predominated in T1 sequence, but in T2, there was variability. Perilesional edema and ring contrast enhancement occurred in 100% of lesions, but eccentric targets and meningeal uptake were less frequent. Conclusion: Even in the presence of single lesions, iso- or hypointense signal in T I, perilesional edema, and ring enhancement are suggestive of cerebral toxoplasmosis. Crown Copyright (c) 2012 Published by Elsevier Inc. All rights reserved.