Enhancement of Antibacterial Effect by Biosynthesized Silver Nanoparticles with Antibiotics

被引：13

作者：

Salunke, Bipinchandra K. ^{[1
]}

Sawant, Shailesh S. ^{[1
]}

Kim, Beom Soo ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Dept Chem Engn, Cheongju 362763, Chungbuk, South Korea

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2016年 / 16卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Antibiotics; Silver Nanoparticles; Hovenia dulcis; Hybrid Drug; Antibacterial Activity; BIOLOGICAL SYNTHESIS; THIN-FILM; EXTRACT; LATEX;

D O I：

10.1166/jnn.2016.11321

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The bark extract of medicinal plant Hovenia dulcis was used for rapid, low cost, and ecofriendly synthesis of silver nanoparticles (AgNPs). The biosynthesized AgNPs demonstrated absorption peak at 433 nm in UV-visible spectroscopy and binding energies at 368.2 and 374 eV in X-ray photoelectron spectroscopy. Transmission electron microscopy micrographs of AgNPs exhibited spherical shapes with average size of 33 nm and selected area electron diffraction pattern suggested their crystalline nature. Fourier transform-infrared spectroscopy analysis revealed role of plant metabolites as reducing and capping agent in synthesis of AgNPs. Enhancement of antibacterial potential of biosynthesized AgNPs after combination with ten different antibiotics with diverse documented mode of action is reported in the present study. The antibacterial effect of AgNP combination with antibiotics was observed to be synergistic. The highest synergistic effects were 3.04 folds for Penicillin against Bacillus cereus and 1.55 folds for Tetracycline against Escherichia coli. This unique property of AgNPs can be therapeutically valuable for fabrication of innovative hybrid drugs for enhancing effectiveness of antibiotics to kill bacteria.

引用

页码：7191 / 7194

页数：4

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