Recent Advances in Extracellular Vesicle-Based Therapies Using Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells

被引：19
作者：
Bertolino, Giuliana Minani [1 ]
Maumus, Marie [1 ,2 ]
Jorgensen, Christian [1 ,3 ]
Noel, Daniele [1 ,3 ]
机构：
[1] Univ Montpellier, INSERM, IRMB, F-34295 Montpellier, France
[2] IRMB, Bauerfeind France, F-34295 Montpellier, France
[3] CHU Montpellier, Dept Rheumatol, Clin Immunol & Osteoarticular Dis Therapeut Unit, F-34095 Montpellier, France
来源：
BIOMEDICINES | 2022年 / 10卷 / 09期
关键词：
regenerative medicine; manufacturing; induced pluripotent stem cells; mesenchymal stromal cells; extracellular vesicles; INTEGRATION-FREE; EXOSOMES; MSCS; INFLAMMATION; ISCHEMIA; DISEASE; INJURY; LIVER;
D O I：
10.3390/biomedicines10092281
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs) are being widely investigated as acellular therapeutics in regenerative medicine applications. EVs isolated from mesenchymal stromal cells (MSCs) are by far the most frequently used in preclinical models for diverse therapeutic applications, including inflammatory, degenerative, or acute diseases. Although they represent promising tools as cell-free therapeutic agents, one limitation to their use is related to the batch-to-batch unreliability that may arise from the heterogeneity between MSC donors. Isolating EVs from MSCs derived from induced pluripotent stem cells (iMSCs) might allow unlimited access to cells with a more stable phenotype and function. In the present review, we first present the latest findings regarding the functional aspects of EVs isolated from iMSCs and their interest in regenerative medicine for the treatment of various diseases. We will then discuss future directions for their translation to clinics with good manufacturing practice implementation.
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页数：16
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