A Myriad of Pathways to NASH

被引：34

作者：

Larrain, Soledad ^{[1
]}

Rinella, Mary E. ^{[1
]}

机构：

[1] Northwestern Univ, Div Gastroenterol & Hepatol, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CLINICS IN LIVER DISEASE | 2012年 / 16卷 / 03期

关键词：

Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; NASH; Drug; Nutrition; Endocrine; Metabolism; NONALCOHOLIC FATTY LIVER; INTESTINAL BACTERIAL OVERGROWTH; MITOCHONDRIAL BETA-OXIDATION; INFLAMMATORY-BOWEL-DISEASE; HEPATIC CB1 RECEPTORS; CHAIN ACYL-COENZYME; PLASMA-FREE CHOLINE; GROWTH-HORMONE; PARENTERAL-NUTRITION; INSULIN-RESISTANCE;

D O I：

10.1016/j.cld.2012.05.009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic steatohepatitis (NASH) is defined histopathologically by the presence of macrovesicular steatosis, cellular ballooning, and inflammation. NASH represents a complex multifactorial disease that typically occurs within the context of the metabolic syndrome. NASH lacks homogeneity, and other forms of NASH can present atypically. Less than 50% of patients with NASH respond to pharmacologic treatment, which speaks to this heterogeneity. The authors discuss drugs, disease entities, and nutritional states that can cause or exacerbate underlying NASH indirectly through worsening insulin resistance or directly by interfering with lipid metabolism, promoting oxidative injury, or activating inflammatory pathways.

引用

页码：525 / +

页数：26

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