The role of the gut/brain axis in modulating food intake

被引：122
作者：
Sam, Amir H. [1 ]
Troke, Rachel C. [1 ]
Tan, Tricia M. [1 ]
Bewick, Gavin A. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Sect Investigat Med, London W12 0NN, England
来源：
NEUROPHARMACOLOGY | 2012年 / 63卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 美国国家卫生研究院; 英国医学研究理事会;
关键词：
Peptide YY (PYY); Glucagon like peptide-1 (GLP-1); Oxyntomodulin; Cholecystokinin; Ghrelin; Obesity; GLUCAGON-LIKE PEPTIDE-1; CENTRAL-NERVOUS-SYSTEM; PLASMA GHRELIN LEVELS; SPONTANEOUS MEAL SIZE; FATTY-ACID RECEPTOR; BODY-WEIGHT GAIN; PANCREATIC-POLYPEPTIDE; NEUROPEPTIDE-Y; GLYCEMIC CONTROL; GASTRIC BYPASS;
D O I：
10.1016/j.neuropharm.2011.10.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity. This article is part of a Special Issue entitled 'Central Control Food Intake' Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：46 / 56
页数：11
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