The role of the gut/brain axis in modulating food intake

被引：122

作者：

Sam, Amir H. ^{[1
]}

Troke, Rachel C. ^{[1
]}

Tan, Tricia M. ^{[1
]}

Bewick, Gavin A. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sect Investigat Med, London W12 0NN, England

来源：

NEUROPHARMACOLOGY | 2012年 / 63卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

Peptide YY (PYY); Glucagon like peptide-1 (GLP-1); Oxyntomodulin; Cholecystokinin; Ghrelin; Obesity; GLUCAGON-LIKE PEPTIDE-1; CENTRAL-NERVOUS-SYSTEM; PLASMA GHRELIN LEVELS; SPONTANEOUS MEAL SIZE; FATTY-ACID RECEPTOR; BODY-WEIGHT GAIN; PANCREATIC-POLYPEPTIDE; NEUROPEPTIDE-Y; GLYCEMIC CONTROL; GASTRIC BYPASS;

D O I：

10.1016/j.neuropharm.2011.10.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity. This article is part of a Special Issue entitled 'Central Control Food Intake' Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

引用

页码：46 / 56

页数：11

共 187 条

[1] The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat [J].

Abbott, CR ;

Small, CJ ;

Sajedi, A ;

Smith, KL ;

Parkinson, JRC ;

Broadhead, LL ;

Ghatei, MA ;

Bloom, SR .

INTERNATIONAL JOURNAL OF OBESITY, 2006, 30 (02) :288-292

[2] Blockade of the neuropeptide YY2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake [J].

Abbott, CR ;

Small, CJ ;

Kennedy, AR ;

Neary, NM ;

Sajedi, A ;

Ghatei, MA ;

Bloom, SR .

BRAIN RESEARCH, 2005, 1043 (1-2) :139-144

[3] The inhibitory effects of peripheral administration of peptide YY3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway [J].

Abbott, CR ;

Monteiro, M ;

Small, CJ ;

Sajedi, A ;

Smith, KL ;

Parkinson, JRC ;

Ghatei, MA ;

Bloom, SR .

BRAIN RESEARCH, 2005, 1044 (01) :127-131

[4] Long-term mortality after gastric bypass surgery [J].

Adams, Ted D. ;

Gress, Richard E. ;

Smith, Sherman C. ;

Halverson, R. Chad ;

Simper, Steven C. ;

Rosamond, Wayne D. ;

LaMonte, Michael J. ;

Stroup, Antoinette M. ;

Hunt, Steven C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (08) :753-761

[5] LACK OF EFFECT OF PANCREATIC-POLYPEPTIDE IN THE RATE OF GASTRIC-EMPTYING AND GUT HORMONE-RELEASE DURING BREAKFAST [J].

ADRIAN, TE ;

GREENBERG, GR ;

FITZPATRICK, ML ;

BLOOM, SR .

DIGESTION, 1981, 21 (04) :214-218

[6] INHIBITION OF SECRETIN STIMULATED PANCREATIC-SECRETION BY PANCREATIC POLYPEPTIDE [J].

ADRIAN, TE ;

BESTERMAN, HS ;

MALLINSON, CN ;

GREENBERG, GR ;

BLOOM, SR .

GUT, 1979, 20 (01) :37-40

[7] DISTRIBUTION AND RELEASE OF HUMAN PANCREATIC POLYPEPTIDE [J].

ADRIAN, TE ;

BLOOM, SR ;

BRYANT, MG ;

POLAK, JM ;

HEITZ, P ;

BARNES, AJ .

GUT, 1976, 17 (12) :940-944

[8] HUMAN DISTRIBUTION AND RELEASE OF A PUTATIVE NEW GUT HORMONE, PEPTIDE-YY [J].

ADRIAN, TE ;

FERRI, GL ;

BACARESEHAMILTON, AJ ;

FUESSL, HS ;

POLAK, JM ;

BLOOM, SR .

GASTROENTEROLOGY, 1985, 89 (05) :1070-1077

[9]

[Anonymous], INT J OBES LOND

[10] CHOLECYSTOKININ ELICITS COMPLETE BEHAVIORAL SEQUENCE OF SATIETY IN RATS [J].

ANTIN, J ;

GIBBS, J ;

HOLT, J ;

YOUNG, RC ;

SMITH, GP .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1975, 89 (07) :784-790

← 1 2 3 4 5 6 7 8 9 10 →