Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city

被引：36

作者：

Sentis, Alexis ^{[1
]}

Martin-Sanchez, Mario ^{[1
,2
]}

Arando, Maider ^{[3
]}

Vall, Marti ^{[3
]}

Jesus Barbera, Maria ^{[3
]}

Ocana, Inma ^{[3
]}

Gonzalez Cordon, Ana ^{[4
,16
]}

Alsina, Merce ^{[4
]}

Martin-Ezquerra, Gemma ^{[5
]}

Knobel, Hernando ^{[5
]}

Gurgui, Merce ^{[6
]}

Vives, Alvaro ^{[7
]}

Coll, Josep ^{[8
]}

Artur Cayla, Joan ^{[1
,9
,10
]}

Garcia de Olalla, Patricia ^{[1
,9
]}

Rius, Cristina ^{[11
]}

Gil, Sonia ^{[11
]}

Gorrindo, Pilar ^{[11
]}

Clos, Roser ^{[11
]}

Sanchez, Raquel ^{[11
]}

Ros, Miriam ^{[11
]}

Masdeu, Eva ^{[11
]}

Simon, Pere ^{[11
]}

Santoma, Maria Jose ^{[11
]}

Armengol, Pere ^{[12
]}

Curran, Adria ^{[12
]}

Ribera, Esteve ^{[12
]}

Falco, Vicenc ^{[12
]}

Gracia Mateo, Maria ^{[13
]}

Mar Gutierrez, M. ^{[13
]}

Domingo, Pere ^{[13
]}

Lopez-Contreras, Joaquin ^{[13
]}

Villar, Judit ^{[14
]}

Guelar, Ana ^{[14
]}

Mothe, Beatriz ^{[15
]}

Fuertes, Irene ^{[16
]}

Gonzalez Cordon, Ana ^{[4
,16
]}

Blanco, Jose L. ^{[16
]}

Garcia, Felipe ^{[16
]}

Mallolas, Josep ^{[16
]}

Miro, Josep M. ^{[16
]}

机构：

[1] Publ Hlth Agcy Barcelona ASPB, Epidemiol Serv, Barcelona, Spain

[2] Pompeu Fabra Univ, ASPB, Parc Salut Mar, Prevent Med & Publ Hlth Training Unit PSMar,UPF, Barcelona, Spain

[3] Univ Autonoma Barcelona, Hosp Vall dHebron, Barcelona, Spain

[4] Univ Barcelona, Hosp Clin Barcelona, Barcelona, Spain

[5] Univ Autonoma Barcelona, Hosp del Mar, Barcelona, Spain

[6] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Barcelona, Spain

[7] Univ Autonoma Barcelona, Hosp Puigvert, Barcelona, Spain

[8] Univ Autonoma Barcelona, Hosp Tries & Pujol, Barcelona, Spain

[9] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[10] Fdn TB Res Unit Barcelona, Barcelona, Spain

[11] ASPB, Barcelona, Spain

[12] Hosp Valle De Hebron, Barcelona, Spain

[13] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[14] Hosp del Mar, Barcelona, Spain

[15] Hosp Germans Tries & Pujol, Barcelona, Spain

[16] Hosp Clin Barcelona, Barcelona, Spain

来源：

BMJ OPEN | 2019年 / 9卷 / 05期

关键词：

ADOLESCENTS; RISK; PREVALENCE; STIS;

D O I：

10.1136/bmjopen-2018-027245

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives Young people are a critical target group for sexually transmitted infections (STI) surveillance due to their particular behavioural and social related vulnerability. The aim of this study was to describe the epidemiological characteristics and trends in the incidence of gonorrhoea, syphilis, HIV and venereal lymphogranuloma (LGV) among 15-24-year-olds in Barcelona, and to determine factors associated with HIV coinfection. Design We performed a population-based incidence study covering the 2007-2015 period. Participants All new cases of STI-HIV, gonorrhoea, infectious syphilis and LGV-notified to the epidemiological surveillance system in Barcelona between 2007 and 2015. 1218 cases were studied: 84.6% were men, 19.3% were 15-19 years old and 50.6% were born in Spain. Among men, 73.7% were men who have sex with men (MSM); among women, 85.6% were women that have sex with men. Primary and secondary outcomes Incidence of HIV, gonorrhoea, infectious syphilis and LGV. HIV coinfection. Results There was an increase in the incidence of gonorrhoea, from 1.9 cases per 10 000 people in 2007 to 7.6/10 000 in 2015 (p<0.01), in MSM from 27.1 to 228.8/10 000 (p<0.01). The incidence of syphilis increased from 0.4/10 000 in 2007 to 3.1/10 000 in 2015 (significant in men only, p<0.01), in MSM from 18.1 to 116.9/10 000 (p<0.01). The incidence of HIV showed a non-significant increase in men (p=0.27), and that of LGV remained stable (p=0.59). Factors associated with increased risk of HIV coinfection included being MSM (adjusted OR[ORa]=14.14, 95% CI 3.34 to 59.91) and having >10 sexual partners (ORa=4.11, 95% CI 1.53 to 11.01) or STI diagnosis during the previous 12 months (ORa=2.06; 95% CI 1.13 to 3.77). Conclusions The incidence of gonorrhoea and syphilis among 15-24-year-olds increased, while HIV infection remained stable but with a high incidence among MSM. Being MSM, having sex with multiple partners and having a diagnosis of an STI in the previous 12 months were factors associated with HIV coinfection.

引用

页数：8

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