Teichoic acid biosynthesis as an antibiotic target

被引：72

作者：

Pasquina, Lincoln W. ^{[1
]}

Maria, John P. Santa ^{[1
]}

Walker, Suzanne ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2013年 / 16卷 / 05期

关键词：

BETA-LACTAM-RESISTANCE; GRAM-POSITIVE BACTERIA; MODIFIER (-)-EPICATECHIN GALLATE; STAPHYLOCOCCUS-AUREUS; LIPOTEICHOIC ACID; CELL-WALL; BACILLUS-SUBTILIS; INHIBITION; MRSA; GLYCOSYLATION;

D O I：

10.1016/j.mib.2013.06.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The relentless spread of antibiotic-resistant pathogens makes it imperative to develop new chemotherapeutic strategies to overcome infection. The bacterial cell wall has served as a rich source for both validated and unexploited pathways that are essential for virulence and survival. Lipoteichoic acids (LTAs) and wall teichoic acids (WTAs) are cell wall polymers that play fundamental roles in Gram-positive bacterial physiology and pathogenesis, and both have been proposed as novel antibacterial targets. Here we describe recent progress toward the discovery of teichoic acid biosynthesis inhibitors and their potential as antibiotics to combat Staphylococcus aureus infections.

引用

页码：531 / 537

页数：7

共 53 条

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