Synthesis of Novel Magnetic Water-Soluble Chitosan as Potential Magnetic Resonance Imaging Contrast Agents

被引：0
作者：
Zhang, Xiaoyan [1 ]
Zhao, Yingying [1 ]
Han, Tongwei [2 ]
Zhang, Qi [1 ]
机构：
[1] Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang, Peoples R China
[2] Jiangsu Univ, Fac Civil Engn & Mech, Zhenjiang, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Magnetic properties; Chitosan; Magnetic resonance imaging; Contrast agents; IRON-OXIDE NANOPARTICLES; MRI; PARTICLES;
D O I：
10.14233/ajchem.2013.14151
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A magnetic water-soluble chitosan as potential contrast agents for MRI was synthesized by a simple new route. The morphology and structure of the magnetic water-soluble chitosan were characterized by FTIR, FESEM and XRD. The magnetic properties were characterized by in vitro and T-2-weighted FLASH image experiments. In vitro magnetic resonance imaging demonstrates that the magnetic water-soluble chitosan could greatly enhance the contrast for image under magnetic field and the contrast was enhanced with the concentration. The results of T-2-relaxivities indicates that the magnetic water-soluble chitosan provided high relaxivity. The paper presents a new, simple and economic route to preparing magnetic water-soluble chitosan using for potential magnetic resonance imaging contrast agents.
引用
收藏
页码：4953 / 4956
页数：4
相关论文
共 18 条
[1]   Functional recovery after brain lesion - contralateral neuromodulation: an fMRI study [J].
Abo, M ;
Chen, ZG ;
Lai, LJ ;
Reese, T ;
Bjelke, B .
NEUROREPORT, 2001, 12 (07) :1543-1547
[2]  
Baghi M, 2005, ANTICANCER RES, V25, P3665
[3]   An investigation of the toxicity of gadolinium based MRI contrast agents using neutron activation analysis [J].
Bartolini, ME ;
Pekar, J ;
Chettle, DR ;
McNeill, F ;
Scott, A ;
Sykes, J ;
Prato, FS ;
Moran, GR .
MAGNETIC RESONANCE IMAGING, 2003, 21 (05) :541-544
[4]   Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents [J].
Feng, JH ;
Sun, GY ;
Pei, FK ;
Liu, ML .
BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (15) :3359-3366
[5]   Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents [J].
Feng, JH ;
Sun, GY ;
Pei, FK ;
Liu, ML .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2002, 92 (3-4) :193-199
[6]   Starch-coated superparamagnetic nanoparticles as MR contrast agents [J].
Kim, DK ;
Mikhaylova, M ;
Wang, FH ;
Kehr, J ;
Bjelke, B ;
Zhang, Y ;
Tsakalakos, T ;
Muhammed, M .
CHEMISTRY OF MATERIALS, 2003, 15 (23) :4343-4351
[7]   Preparation of nanostructured metal ferrite particles by sonochemistry [J].
Kim, EH ;
Lee, HS ;
Sha, H .
ON THE CONVERGENCE OF BIO-INFORMATION-, ENVIRONMENTAL-, ENERGY-, SPACE- AND NANO-TECHNOLOGIES, PTS 1 AND 2, 2005, 277-279 :1044-1048
[8]   Biomedical applications of superparamagnetic iron oxide nanoparticles encapsulated within chitosan [J].
Kim, Eun Hee ;
Ahn, Yangkyu ;
Lee, Hyo Sook .
JOURNAL OF ALLOYS AND COMPOUNDS, 2007, 434 :633-636
[9]   Avidin-dendrimer-(1B4M-Gd)254:: A tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI [J].
Kobayashi, H ;
Kawamoto, S ;
Saga, T ;
Sato, N ;
Ishimori, T ;
Konishi, J ;
Ono, K ;
Togashi, K ;
Brechbiel, MW .
BIOCONJUGATE CHEMISTRY, 2001, 12 (04) :587-593
[10]   IMAGE FORMATION BY INDUCED LOCAL INTERACTIONS - EXAMPLES EMPLOYING NUCLEAR MAGNETIC-RESONANCE [J].
LAUTERBUR, PC .
NATURE, 1973, 242 (5394) :190-191
12