Estimation of QTL heritability based on pooled sequencing data

被引：13
作者：
Tang, Weiqi [1 ,2 ]
Huang, Likun [1 ,2 ]
Bu, Suhong [1 ,2 ]
Zhang, Xuzhang [1 ,2 ]
Wu, Weiren [1 ,2 ]
机构：
[1] Fujian Agr & Forestry Univ, Coll Life Sci, Key Lab Genet Breeding & Multiple Utilizat Crops, Minist Educ, Fuzhou 350002, Fujian, Peoples R China
[2] Fujian Agr & Forestry Univ, Fujian Key Lab Crop Breeding Design, Fuzhou 350002, Fujian, Peoples R China
来源：
BIOINFORMATICS | 2018年 / 34卷 / 06期
关键词：
BULKED SEGREGANT ANALYSIS; GENETIC ARCHITECTURE; GENOMIC REGIONS; CANDIDATE GENES; COMPLEX TRAIT; IDENTIFICATION; SEQ; TOLERANCE; DISEASE; WEIGHT;
D O I：
10.1093/bioinformatics/btx703
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Motivation: Bulked segregant analysis combined with next generation sequencing has proven to be a simple and efficient approach for fast mapping of quantitative trait loci (QTLs). However, how to estimate the proportion of phenotypic variance explained by a QTL (or termed QTL heritability) in such pooled QTL mapping is an unsolved problem. Results: In this paper, we propose a method called PQHE to estimate QTL heritability using pooled sequencing data obtained under different experimental designs. Simulation studies indicated that our method is correct and feasible. Four practical examples from rice and yeast are demonstrated, each representing a different situation.
引用
收藏
页码：978 / 984
页数：7
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