Recent progress in research on the distribution and function of NUCB2/Nesfatin-1 in peripheral tissues

被引：24

作者：

Cao, Xun ^{[1
]}

Liu, Xiao-Min ^{[1
]}

Zhou, Li-Hong ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Endocrinol, Harbin 150001, Heilongjiang Pr, Peoples R China

来源：

ENDOCRINE JOURNAL | 2013年 / 60卷 / 09期

关键词：

Nesfatin-1; Peripheral tissues; Satiety factor; Metabolic syndrome; INSULIN-SECRETION; MOLECULAR-CLONING; NESFATIN-1; PEPTIDE; NUCB2; NUCLEOBINDIN-2; ASSOCIATION; EXPRESSION; ADIPOKINE; VARIANTS;

D O I：

10.1507/endocrj.EJ13-0236

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nesfatin-1 is a polypeptide derived from the posttranslational processing of the N-terminal fragment of nucleobindin 2 (NUCB2), that was originally identified as an anorexigenic hypothalamic neuropeptide. A number of reports have recently shown that NUCB2/Nesfatin-1 is widely expressed in various peripheral tissues, including those of the gastrointestinal tract where it may participate in various pathophysiological processes. One of its roles may be regulation of energy homeostasis. As a result, Nesfatin-1 may be a novel target for exploring the underlying mechanisms and the treatment of metabolic syndromes.

引用

页码：1021 / 1027

页数：7

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