The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC

被引:15
作者
Rusu, Ioana [1 ,2 ]
Pirlog, Radu [3 ]
Chiroi, Paul [3 ]
Nutu, Andreea [3 ]
Puia, Vlad Radu [2 ,4 ]
Fetti, Alin Cornel [2 ,4 ]
Rusu, Daniel Radu [1 ]
Berindan-Neagoe, Ioana [3 ]
Al Hajjar, Nadim [2 ,4 ]
机构
[1] Reg Inst Gastroenterol & Hepatol, Dept Pathol, Cluj Napoca 400162, Romania
[2] Iuliu Hatieganu Univ Med & Pharm, Dept Gen Surg 3, Cluj Napoca 400186, Romania
[3] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400337, Romania
[4] Reg Inst Gastroenterol & Hepatol, Dept Surg, Cluj Napoca 400162, Romania
关键词
NAFLD; hepatocellular carcinoma; ncRNAs; miRNA; lncRNA; PROMOTES HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; CIRCULATING MICRORNAS; CELL-PROLIFERATION; DOWN-REGULATION; POOR-PROGNOSIS; UP-REGULATION; RISK-FACTORS; EXPRESSION; CANCER;
D O I
10.3390/ijms232012370
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver pathology worldwide. Meanwhile, liver cancer represents the sixth most common malignancy, with hepatocellular carcinoma (HCC) as the primary, most prevalent subtype. Due to the rising incidence of metabolic disorders, NAFLD has become one of the main contributing factors to HCC development. However, although NAFLD might account for about a fourth of HCC cases, there is currently a significant gap in HCC surveillance protocols regarding noncirrhotic NAFLD patients, so the majority of NAFLD-related HCC cases were diagnosed in late stages when survival chances are minimal. However, in the past decade, the focus in cancer genomics has shifted towards the noncoding part of the genome, especially on the microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), which have proved to be involved in the regulation of several malignant processes. This review aims to summarize the current knowledge regarding some of the main dysregulated, noncoding RNAs (ncRNAs) and their implications for NAFLD and HCC development. A central focus of the review is on miRNA and lncRNAs that can influence the progression of NAFLD towards HCC and how they can be used as potential screening tools and future therapeutic targets.
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页数:25
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