Nox2 activation in Covid-19

被引：118

作者：

Violi, Francesco ^{[1
]}

Oliva, Alessandra ^{[2
]}

Cangemi, Roberto ^{[3
]}

Ceccarelli, Giancarlo ^{[2
]}

Pignatelli, Pasquale ^{[1
]}

Carnevale, Roberto ^{[1
,5
]}

Cammisotto, Vittoria ^{[1
]}

Lichtner, Miriam ^{[2
]}

Alessandri, Francesco ^{[4
]}

De Angelis, Massimiliano ^{[2
]}

Miele, Maria Claudia ^{[2
]}

D'Ettorre, Gabriella ^{[2
]}

Ruberto, Franco ^{[4
]}

Venditti, Mario ^{[1
]}

Pugliese, Francesco ^{[1
]}

Mastroianni, Claudio Maria ^{[2
]}

机构：

[1] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy

[2] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy

[3] Sapienza Univ Rome, Dept Translat & Precis Med, Rome, Italy

[4] Sapienza Univ Rome, Dept Gen Surg Paride Stefanini, Rome, Italy

[5] Mediterranea Cardioctr, I-80122 Naples, Italy

来源：

REDOX BIOLOGY | 2020年 / 36卷

关键词：

Covid-19; Nox-2; NADPH oxidase; Thrombosis; PLATELET ACTIVATION; NADPH-OXIDASE; UP-REGULATION; DISEASE; ATHEROTHROMBOSIS;

D O I：

10.1016/j.redox.2020.101655

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.

引用

页数：4

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