Long-term Prognosis and Clinical Characteristics of Patients with Newly Diagnosed Diabetes Mellitus Detected after First Acute Myocardial Infarction: from KAMIR-NIH Registry

被引：8

作者：

Park, Hyun Woong ^{[1
]}

Kang, Min Gyu ^{[1
]}

Kim, Kyehwan ^{[1
]}

Koh, Jin-Sin ^{[1
]}

Park, Jeong Rang ^{[1
]}

Jeong, Young-Hoon ^{[2
]}

Ahn, Jong Hwa ^{[2
]}

Jang, Jeong Yoon ^{[2
]}

Kwak, Choong Hwan ^{[2
]}

Park, Yongwhi ^{[2
]}

Jeong, Myung Ho ^{[3
]}

Kim, Young Jo ^{[4
]}

Cho, Myeong Chan ^{[5
]}

Kim, Chong Jin ^{[6
]}

Hwang, Jin Yong ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Internal Med, Sch Med, 79 Gangnam Ro, Jinju 52727, South Korea

[2] Gyeongsang Natl Univ, Changwon Hosp, Sch Med, Dept Internal Med, Chang Won, South Korea

[3] Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea

[4] Yeungnam Univ Hosp, Dept Internal Med, Daegu, South Korea

[5] Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea

[6] Kyung Hee Univ Hosp, Dept Internal Med, Seoul, South Korea

来源：

KOREAN CIRCULATION JOURNAL | 2018年 / 48卷 / 02期

关键词：

Diabetes mellitus; Myocardial infarction; Cardiac death; Congestive heart failure; PERCUTANEOUS CORONARY INTERVENTION; ASSOCIATION TASK-FORCE; ST-ELEVATION; HOSPITAL MORTALITY; AMERICAN-COLLEGE; HEART-DISEASE; RISK-FACTOR; IMPACT; OUTCOMES; PATHOPHYSIOLOGY;

D O I：

10.4070/kcj.2017.0174

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Objectives: After the first acute myocardial infarction (AMI), a considerable proportion of patients are newly diagnosed with diabetes mellitus (DM). However, in AMI, controversy remains regarding the disparity in prognosis between previously diagnosed DM (known-DM) and newly diagnosed DM (new-DM). Methods: The study included 10,455 patients with AMI (non-DM, 6,236; new-DM, 659; known-DM, 3,560) admitted to one of 15 participating centers in Korea between November 2011 and January 2016 (average follow-up, 523 days). We compared the characteristics and clinical course of patients with known-DM and those with new- or non-DM. Results: Compared to patients with known-DM, those with new-DM or non-DM were younger, more likely to be male, and less likely to have hypertension, dyslipidemia, prior stroke, angina, or myocardial infarction. Compared to patients with new-DM or non-DM (reference), those with known-DM had higher risks of major adverse cardiac events (hazard ratio [HR], 1.20; 95% confidence interval [CI], 1.06-1.35; p=0.004), cardiac death (HR, 1.26; 95% CI, 1.01-1.57; p=0.042), and congestive heart failure (HR, 1.58; 95% CI, 1.20-2.08). Unlike known-DM, new-DM did not increase the risk of cardiac events (including death). Conclusions: Known-DM was associated with a significantly higher risk of cardiovascular events after AMI, while new-DM had a similar risk of cardiac events as that noted for nonDM. There were different cardiovascular outcomes according to diabetes status in patients with AMI.

引用

页码：134 / 147

页数：14

共 30 条

[21] Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006 [J].