Susceptibility Weighted Imaging: A New Tool in the Diagnosis of Prostate Cancer and Detection of Prostatic Calcification

被引:36
作者
Bai, Yan [1 ]
Wang, Mei-Yun [1 ]
Han, Yan-Hong [1 ]
Dou, She-Wei [1 ]
Lin, Qing [1 ]
Guo, Ying [1 ]
Li, Wei [1 ,5 ]
Ding, De-Gang [2 ]
Dai, Jian-Ping [1 ]
Qin, Wei
Shi, Da-Peng [1 ]
Tian, Jie [4 ]
Dai, Yong-Ming [3 ]
机构
[1] Henan Prov Peoples Hosp, Dept Radiol, Zhengzhou, Henan, Peoples R China
[2] Henan Prov Peoples Hosp, Dept Urinary Surg, Zhengzhou, Henan, Peoples R China
[3] Siemens Healthcare, MRI, Shanghai, Peoples R China
[4] Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
[5] Xidian Univ, Sch Sci & Technol, Life Sci Res Ctr, Xian, Shanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
GROWTH-FACTOR VEGF; CEREBRAL MICROBLEEDS; MR; BRAIN; INJURY; TUMOR; CT;
D O I
10.1371/journal.pone.0053237
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Susceptibility weighted imaging (SWI) is a new MRI technique which has been proved very useful in the diagnosis of brain diseases, but few study was performed on its value in prostatic diseases. The aim of the present study was to investigate the value of SWI in distinguishing prostate cancer from benign prostatic hyperplasia and detecting prostatic calcification. Methodology/Principal Findings: 23 patients with prostate cancer and 53 patients with benign prostatic hyperplasia proved by prostate biopsy were scanned on a 3.0T MR and a 16-row CT scanner. High-resolution SWI, conventional MRI and CT were performed on all patients. The MRI and CT findings, especially SWI, were analyzed and compared. The analyses revealed that 19 out of 23 patients with prostate cancer presented hemorrhage within tumor area on SWI. However, in 53 patients with benign prostatic hyperplasia, hemorrhage was detected only in 1 patient in prostate by SWI. When comparing SWI, conventional MRI and CT in detecting prostate cancer hemorrhage, out of the 19 patients with prostate cancer who had prostatic hemorrhage detected by SWI, the prostatic hemorrhage was detected in only 7 patients by using conventional MRI, and none was detected by CT. In addition, CT demonstrated calcifications in 22 patients which were all detected by SWI whereas only 3 were detected by conventional MRI. Compared to CT, SWI showed 100% in the diagnostic sensitivity, specificity, accuracy, positive predictive value(PPV) and negative predictive value(NPV) in detecting calcifications in prostate but conventional MRI demonstrated 13.6% in sensitivity, 100% in specificity, 75% in accuracy, 100% in PPV and 74% in NPV. Conclusions: More apparent prostate hemorrhages were detected on SWI than on conventional MRI or CT. SWI may provide valuable information for the differential diagnosis between prostate cancer and prostatic hyperplasia. Filtered phase images can identify prostatic calcifications as well as CT.
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页数:7
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