Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells

被引：41
作者：
Akkouche, Abdou [1 ]
Grentzinger, Thomas [2 ]
Fablet, Marie [1 ]
Armenise, Claudia [2 ]
Burlet, Nelly [1 ]
Braman, Virginie [1 ]
Chambeyron, Severine [2 ]
Vieira, Cristina [1 ,3 ]
机构：
[1] Univ Lyon 1, Univ Lyon, CNRS, UMR5558,Lab Biomet & Biol Evolut, F-69622 Villeurbanne, France
[2] Ctr Natl Rech Scientif, Inst Genet Humaine, F-34396 Montpellier, France
[3] Inst Univ France, Paris, France
来源：
EMBO REPORTS | 2013年 / 14卷 / 05期
关键词：
histone modifications; piRNA; somatic regulation; transposable elements; GYPSY ENDOGENOUS RETROVIRUS; DROSOPHILA-MELANOGASTER; SMALL-RNA; PIWI; CHROMATIN; PATHWAY; TRANSPOSONS; TRANSCRIPTS; INVASION; ELEMENT;
D O I：
10.1038/embor.2013.38
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transposable elements (TEs), whose propagation can result in severe damage to the host genome, are silenced in the animal gonad by Piwi-interacting RNAs (piRNAs). piRNAs produced in the ovaries are deposited in the embryonic germline and initiate TE repression in the germline progeny. Whether the maternally transmitted piRNAs play a role in the silencing of somatic TEs is however unknown. Here we show that maternally transmitted piRNAs from the tirant retrotransposon in Drosophila are required for the somatic silencing of the TE and correlate with an increase in histone H3K9 trimethylation an active tirant copy.
引用
收藏
页码：458 / 464
页数：7
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