The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3'-dimethylaminopropyl)phenothiazine-S]-palladium(II)

Palladium(II) complexes of phenothiazines were synthesized and examined for their antiplasmid activity on E. coli. It was found that the complex of unsubstituted phenothiazine was ineffective; however, the complexes of chlorpromazine and promazine were able to eliminate the F'lac plasmid of E. coli and inhibited intercellular plasmid transfer. The crystal structure of [Pd(pzH)Cl-3] (pzH is protonated promazine) has been determined by X-ray diffraction methods and refined to a residual of 0.028 for 2821 independent observed reflections. The crystals are monoclinic, space group P2(1)/n; a 8.166(2); b 26.855(5); c 9.141(2) Angstrom; beta 110.65(2)degrees. Promazine is bonded via an S atom to a PdCl3- unit with the charge being balanced by a protonated amino group.