Recent advances on the roles of LncRNAs in cardiovascular disease

被引：56

作者：

Fang, Yexian ^{[1
]}

Xu, Yuerong ^{[2
]}

Wang, Runze ^{[1
]}

Hu, Lang ^{[1
]}

Guo, Dong ^{[1
]}

Xue, Feng ^{[1
]}

Guo, Wangang ^{[1
]}

Zhang, Dongwei ^{[1
]}

Hu, Jianqiang ^{[1
]}

Li, Yan ^{[1
]}

Zhang, Wei ^{[1
]}

Zhang, Mingming ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Cardiol, Xian 710038, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Sch Stomatol, Dept Orthodont, Xian, Shaanxi, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 21期

基金：

中国国家自然科学基金;

关键词：

biological function; cardiovascular diseases; Long Non-coding RNA; LONG NONCODING RNA; MYOCARDIAL-INFARCTION; HEART; AUTOPHAGY; ATHEROSCLEROSIS; INHIBITION; TRANSCRIPT; RISK;

D O I：

10.1111/jcmm.15880

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiovascular diseases are a main cause of mortality whose prevalence continues to increase worldwide. Long non-coding RNAs (lncRNAs) regulate a variety of biological processes by modifying and regulating transcription of coding genes, directly binding to proteins and even coding proteins themselves. LncRNAs play key roles in the occurrence and development of myocardial infarction, heart failure, myocardial hypertrophy, arrhythmias and other pathological processes that significantly affect the prognosis and survival of patients with cardiovascular diseases. We here review the latest research on lncRNAs in cardiovascular diseases as a basis to formulate future research on prevention and treatment of cardiovascular diseases.

引用

页码：12246 / 12257

页数：12

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