Familial hypercholesterolaemia: new treatment options

被引：0
作者：
Ezzahti, M. [1 ]
Sijbrands, E. J. G. [1 ]
Mulder, M. T. [1 ]
van Lennep, J. E. Roeters [1 ]
机构：
[1] Erasmus MC, Dept Vasc Med, Rotterdam, Netherlands
来源：
NETHERLANDS JOURNAL OF MEDICINE | 2013年 / 71卷 / 05期
关键词：
Familial hypercholesterolemia; treatment; PCSK9; apolipoprotein B; synthesis inhibitor; CETP; MTP; ESTER TRANSFER PROTEIN; TRIGLYCERIDE TRANSFER PROTEIN; DENSITY-LIPOPROTEIN CHOLESTEROL; PLACEBO-CONTROLLED TRIAL; CORONARY-HEART-DISEASE; B SYNTHESIS INHIBITOR; APOLIPOPROTEIN-B; LOWERING TREATMENT; HIGH-RISK; MONOCLONAL-ANTIBODY;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Familial hypercholesterolaemia is a relatively frequently occurring disease that is strongly associated with vascular disease. Current treatment with cholesterol-lowering agents is partly effective but shows variable responses between patients with familial hypercholesterolaemia. Recently, new cholesterol-lowering drugs have been developed. Here we describe the most promising of these new agents for which results from phase 2 or phase 3 trials are available. We will discuss the data regarding lipid-lowering potential and safety issues and speculate about the potential reductions of the residual risk of statin-treated FH patients.
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收藏
页码：227 / 233
页数：7
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