Familial hypercholesterolaemia: new treatment options

被引：0

作者：

Ezzahti, M. ^{[1
]}

Sijbrands, E. J. G. ^{[1
]}

Mulder, M. T. ^{[1
]}

van Lennep, J. E. Roeters ^{[1
]}

机构：

[1] Erasmus MC, Dept Vasc Med, Rotterdam, Netherlands

来源：

NETHERLANDS JOURNAL OF MEDICINE | 2013年 / 71卷 / 05期

关键词：

Familial hypercholesterolemia; treatment; PCSK9; apolipoprotein B; synthesis inhibitor; CETP; MTP; ESTER TRANSFER PROTEIN; TRIGLYCERIDE TRANSFER PROTEIN; DENSITY-LIPOPROTEIN CHOLESTEROL; PLACEBO-CONTROLLED TRIAL; CORONARY-HEART-DISEASE; B SYNTHESIS INHIBITOR; APOLIPOPROTEIN-B; LOWERING TREATMENT; HIGH-RISK; MONOCLONAL-ANTIBODY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Familial hypercholesterolaemia is a relatively frequently occurring disease that is strongly associated with vascular disease. Current treatment with cholesterol-lowering agents is partly effective but shows variable responses between patients with familial hypercholesterolaemia. Recently, new cholesterol-lowering drugs have been developed. Here we describe the most promising of these new agents for which results from phase 2 or phase 3 trials are available. We will discuss the data regarding lipid-lowering potential and safety issues and speculate about the potential reductions of the residual risk of statin-treated FH patients.

引用

页码：227 / 233

页数：7

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