Regiocontrolled synthesis of the trimeric quinone framework of conocurvone

被引：35

作者：

Emadi, A ^{[1
]}

Harwood, JS

Kohanim, S

Stagliano, KW

机构：

[1] IIT, Dept Biol Chem & Phys Sci, Chicago, IL 60616 USA

[2] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 04期

关键词：

D O I：

10.1021/ol010272m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The trimeric quinone framework of conocurvone is crucial for its potent anti-HIV activity. A new synthesis of trimeric quinones based on stepwise substitution of the halogens in 2,3-dihaloquinones by hydroxyquinone anions is described. Chlorinated biquinones are key intermediates that undergo regiospecific substitution reactions to yield trimeric quinone monomethyl ethers.

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收藏

页码：521 / 524

页数：4

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