Development and Impact of Human Papillomavirus Vaccines

被引：7
作者：
Darus, Christopher J. [1 ]
Mueller, Jennifer J. [1 ]
机构：
[1] Maine Med Ctr, Div Gynecol Oncol, Portland, OR USA
来源：
CLINICAL OBSTETRICS AND GYNECOLOGY | 2013年 / 56卷 / 01期
关键词：
human papillomavirus; vaccine; cervical cancer; cervical intraepithelial neoplasia; CERVICAL-CANCER; HPV VACCINE; PROTECTION; INFECTION; OUTCOMES; HEALTH;
D O I：
10.1097/GRF.0b013e31827af770
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Cervical cancer is a global health crisis that disproportionately affects developing nations and underserved populations. Two vaccines targeting HPV-16 and 18, which account for 70% of invasive cervical carcinomas, are licensed in the United States and numerous countries worldwide. Both vaccine formulations have shown excellent efficacy with minimal toxicity. Numerous questions remain, including cost-effectiveness, vaccination of males, societal acceptance of HPV vaccination, and cervical dysplasia screening in the HPV-immunized population. Access to vaccination for underserved populations both in developed and resource-poor nations remains an issue. Multivalent vaccines that encompass additional oncogenic HPV strains are under development.
引用
收藏
页码：10 / 16
页数：7
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