Attenuation of growth suppression activity of deleted in liver cancer 1 (DLC1) tumor suppressor by Akt phoshorylation

被引：0
|
作者：
Yam, Judy [1 ]
Ko, Frankie [1 ]
Chan, Lo-Kong [1 ]
Ng, Irene [1 ]
机构：
[1] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
来源：
CANCER RESEARCH | 2009年 / 69卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
423
引用
收藏
页数：1
相关论文
共 50 条
  • [21] Functional Interaction of Tumor Suppressor DLC1 and Caveolin-1 in Cancer Cells
    Du, Xiaoli
    Qian, Xiaolan
    Papageorge, Alex
    Schetter, Aaron J.
    Vass, William C.
    Liu, Xi
    Braverman, Richard
    Robles, Ana I.
    Lowy, Douglas R.
    CANCER RESEARCH, 2012, 72 (17) : 4405 - 4416
  • [22] Nuclear-Targeted Deleted in Liver Cancer 1 (DLC1) Is Less Efficient in Exerting Its Tumor Suppressive Activity Both In Vitro and In Vivo
    Chan, Lo-Kong
    Ko, Frankie Chi Fat
    Sze, Karen Man-Fong
    Ng, Irene Oi-Lin
    Yam, Judy Wai Ping
    PLOS ONE, 2011, 6 (09):
  • [23] Complex formation between the DLC1 START domain and Cav1 contributes to the tumor suppressor function of DLC1
    Du, Xiaoli
    Qian, Xiaolan
    Papageorge, Alex
    Vass, William C.
    Braverman, Richard
    Lowy, Douglas R.
    CANCER RESEARCH, 2011, 71
  • [24] Deleted in Liver Cancer 1 (DLC1) Negatively Regulates Rho/ROCK/MLC Pathway in Hepatocellular Carcinoma
    Wong, Carmen Chak-Lui
    Wong, Chun-Ming
    Ko, Frankie Chi-Fat
    Chan, Lo-Kong
    Ching, Yick-Pang
    Yam, Judy Wai-Ping
    Ng, Irene Oi-Lin
    PLOS ONE, 2008, 3 (07):
  • [25] Epigenetic reactivation of the DLC1 tumor suppressor protein is a new approach for cancer treatment
    Tripathi, Brajendra K.
    Boccuzzi, Luciarita
    Anderman, Meghan
    Qian, Xiaolan
    Walters, Kylie J.
    Doroshow, James H.
    Lowy, Douglas R.
    CANCER RESEARCH, 2020, 80 (16)
  • [26] Deleted in Liver Cancer 1 (DLC1) is a negative regulator of metastasis and deregulated by kinase phosphorylation in hepatocellular carcinoma
    Ko, Frankie Chi Fat
    Chan, Lo-Kong
    Tung, Edmund Kwok Kwan
    Ng, Irene Oi-Lin
    Yam, Judy Wai Ping
    CANCER RESEARCH, 2010, 70
  • [27] The tumor suppressor DLC1 inhibits cancer progression and oncogenic autophagy in hepatocellular carcinoma
    Wu, Hui-Ta
    Xie, Cheng-Rong
    Lv, Jie
    Qi, He-Qiang
    Wang, Fei
    Zhang, Sheng
    Fang, Qin-Liang
    Wang, Fu-Qiang
    Lu, Yu-Yan
    Yin, Zhen-Yu
    LABORATORY INVESTIGATION, 2018, 98 (08) : 1014 - 1024
  • [28] CDK5 is a major regulator of the tumor suppressor DLC1
    Tripathi, Brajendra K.
    Qian, Xiaolan
    Mertins, Philipp
    Wang, Dunrui
    Papageorge, Alex G.
    Carr, Steven A.
    Lowy, Douglas R.
    JOURNAL OF CELL BIOLOGY, 2014, 207 (05): : 627 - 642
  • [29] Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis
    Ko, Frankie Chi Fat
    Yeung, Yin-Shan
    Mao, Xiaowen
    Yam, Judy Wai Ping
    CANCER RESEARCH, 2014, 74 (19)
  • [30] AKT positively regulates Rho-GTP by attenuating the GAP activity of the DLC1 tumor suppressor: a mechanistic study with translational implications
    Tripathi, Brajendra K.
    Grant, Tiera
    Mertins, Philipp
    Qian, Xiaolan
    Wang, Dunrui
    Papageorge, Alex G.
    Carr, Steven A.
    Lowy, Douglas R.
    CANCER RESEARCH, 2016, 76
12345