Mitochondrial-mediated antiviral immunity

被引：105

作者：

Koshiba, Takumi ^{[1
]}

机构：

[1] Kyushu Univ, Fac Sci, Dept Biol, Higashi Ku, Fukuoka 8128581, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2013年 / 1833卷 / 01期

关键词：

Antiviral innate immunity; MAVS; Mitochondrial dynamics; RLR pathway; Signal transduction; NF-KAPPA-B; RIG-I; SIGNALING PROTEIN; ADAPTER PROTEIN; INNATE IMMUNITY; INFLAMMATORY RESPONSES; PEROXISOMAL FISSION; STRUCTURAL BASIS; CELL-DEATH; MAVS;

D O I：

10.1016/j.bbamcr.2012.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria, cellular powerhouses of eukaryotes, are known to act as central hubs for multiple signal transductions. Recent research reveals that mitochondria are involved in cellular innate antiviral immunity in vertebrates, particularly mammals. Mitochondrial-mediated antiviral immunity depends on the activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and on the participation of a mitochondrial outer membrane adaptor protein, called the "mitochondrial antiviral signaling (MAVS)". In this review, we discuss unexpected discoveries that are revealing how the organelles contribute to the innate immune response against RNA viruses. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：225 / 232

页数：8

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