ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice

被引：8

作者：

Moreau, Pierre-Henri ^{[1
]}

Bott, Jean-Bastien ^{[1
]}

Zerbinatti, Celina ^{[2
]}

Renger, John Joseph ^{[2
]}

Kelche, Christian ^{[1
]}

Cassel, Jean-Christophe ^{[1
]}

Mathis, Chantal ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, UMR 7237, Lab Imagerie & Neurosci Cognit,GDR CNRS 2905,IFR, F-67000 Strasbourg, France

[2] Merck Sharp & Dohme Corp, Dept Neurosymptomat Disorders, West Point, PA 19486 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2013年 / 243卷

关键词：

Antagonist pleiotropic effect; Apolipoprotein E; Cognition; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN-E; TRANSGENIC MICE; COGNITIVE PERFORMANCE; EPSILON-4; E4; RECEPTORS; CHILDREN; SEX; APP;

D O I：

10.1016/j.bbr.2012.12.043

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The APOE-epsilon 4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-epsilon 4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-epsilon 4 on cognitive functions. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1 / 5

页数：5

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