Fabrication of Multifunctional Gd2O3/Au Hybrid Nanoprobe via a One-Step Approach for Near-Infrared Fluorescence and Magnetic Resonance Multimodal Imaging in Vivo

被引：125

作者：

Sun, Shao-Kai ^{[1
,2
]}

Dong, Lu-Xi ^{[1
,2
]}

Cao, Yang ^{[3
]}

Sun, Hao-Ran ^{[3
]}

Yan, Xiu-Ping ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab Med Chem Biol, Synerget Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

[2] Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China

[3] Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2013年 / 85卷 / 17期

基金：

中国国家自然科学基金;

关键词：

QUANTUM DOTS; NANOPARTICLES; CANCER; NANOCOMPOSITES; POLYMER; PROBES; SHELL; CORE; MR;

D O I：

10.1021/ac401879y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Facile fabrication of multimodal imaging probes is highly desired for bioimaging application due to their integrated advantages of several imaging modalities. Here, we report a simple and one-step mild strategy to fabricate a multifunctional Gd2O3/Au hybrid nanoprobe. Bovine serum albumin (BSA) was used as the template in the biomineralization synthesis. The fabricated BSA-Gd2O3/Au nanoprobe showed excellent chemical stability, intense near-infrared (NIR) fluorescence, and good magnetic resonance imaging (MRI) ability. The multimodal imaging potential of the prepared multifunctional nanoprobe was demonstrated by successful NIR fluorescent and magnetic resonance blood pool imaging. Further modification of BSA-Gd2O3/Au with arginine-glycine-aspartic acid peptide c(RGDyK) (RGD) enabled the nanoprobe for targeted tumor imaging in vivo.

引用

页码：8436 / 8441

页数：6

共 43 条

[1] Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology [J].

Cheon, Jinwoo ;

Lee, Jae-Hyun .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (12) :1630-1640

[2] Molecular imaging of cancer with positron emission tomography [J].

Gambhir, SS .

NATURE REVIEWS CANCER, 2002, 2 (09) :683-693

[3] Fluorescent Ag Clusters via a Protein-Directed Approach as a Hg(II) Ion Sensor [J].

Guo, Cunlan ;

Irudayaraj, Joseph .

ANALYTICAL CHEMISTRY, 2011, 83 (08) :2883-2889

[4] Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives [J].

Hahn, Megan A. ;

Singh, Amit K. ;

Sharma, Parvesh ;

Brown, Scott C. ;

Moudgil, Brij M. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2011, 399 (01) :3-27

[5] In Vivo Study of Biodistribution and Urinary Excretion of Surface-Modified Silica Nanoparticles [J].

He, Xiaoxiao ;

Nie, Hailong ;

Wang, Kemin ;

Tan, Weihong ;

Wu, Xu ;

Zhang, Pengfei .

ANALYTICAL CHEMISTRY, 2008, 80 (24) :9597-9603

[6] Real-time strain rate imaging of the left ventricle by ultrasound [J].

Heimdal, A ;

Stoylen, A ;

Torp, H ;

Skjaerpe, T .

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 1998, 11 (11) :1013-1019

[7] Hybrid gold-gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo [J].

Hu, De-Hong ;

Sheng, Zong-Hai ;

Zhang, Peng-Fei ;

Yang, Da-Zhi ;

Liu, Shu-Hui ;

Gong, Ping ;

Gao, Du-Yang ;

Fang, Sheng-Tao ;

Ma, Yi-Fan ;

Cai, Lin-Tao .

NANOSCALE, 2013, 5 (04) :1624-1628

[8] Gd3+-functionalized near-infrared quantum dots for in vivo dual modal (fluorescence/magnetic resonance) imaging [J].

Jin, Takashi ;

Yoshioka, Yoshichika ;

Fujii, Fumihiko ;

Komai, Yutaka ;

Seki, Junji ;

Seiyama, Akitoshi .

CHEMICAL COMMUNICATIONS, 2008, (44) :5764-5766

[9]

Johnson K. A., 1998, Neurology, V50, P1563

[10] Europium-doped gadolinium sulfide nanoparticles as a dual-mode imaging agent for T1-weighted MR and photoluminescence imaging [J].

Jung, Jongjin ;

Kim, Mi Ae ;

Cho, Jee-Hyun ;

Lee, Seung Jae ;

Yang, Ilseung ;

Cho, Janggeun ;

Kim, Seong Keun ;

Lee, Chulhyun ;

Park, Joung Kyu .

BIOMATERIALS, 2012, 33 (24) :5865-5874

← 1 2 3 4 5 →