Catalyst-free synthesis of benzofuran-fused pyrido [4,3-d]pyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions

被引：10

作者：

Li, Bo ^{[1
,2
]}

Yue, Zhizhou ^{[1
]}

Xiang, Haoyue ^{[2
]}

Lv, Linlin ^{[1
]}

Song, Shanshan ^{[2
]}

Miao, Zehong ^{[2
]}

Yang, Chunhao ^{[2
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Engn, Dept Pharmaceut Engn, Wuhan 430070, Hubei, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 01期

基金：

中国国家自然科学基金;

关键词：

CASCADE REACTIONS; TOPOISOMERASE-I; INHIBITORS; DISCOVERY; POTENT; ACID; IDENTIFICATION; CONSTRUCTION; DERIVATIVES; ANTITUMOR;

D O I：

10.1039/c3ra44828b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid, one-pot, catalyst-free approach to novel benzofuran-fused pyrido[4,3-d]pyrimidines with good antitumor activities via a cascade SNAr/cyclization/condensation reaction through 2-(2-hydroxyphenyl) acetonitriles and 4,6-dichloropyrimidine-5-carbaldehyde was developed.

引用

页码：358 / 364

页数：7

共 4 条

[1] Facile synthesis of pyrido[2,3-d]pyrimidines via cyclocondensation of 4,6-dichloro-2-methylsulfanylpyrimidine-5-carbaldehyde with β-substituted β-aminoacrylic esters
Chizhova, Maria E.
Bakulina, Olga Yu.
Ivanov, Alexander Yu.
Lobanov, Pavel S.
Dar'in, Dmitrii V.
TETRAHEDRON, 2015, 71 (36) : 6196 - 6203
[2] Green metal-free synthesis of spiro-fused 3,4-pyrazolo[4,3:5,6]pyrido[2,3-d]pyrimidine derivatives via deamination cyclization reactions in aqueous medium
Dai, Lei
Mao, Kaimin
Pan, Zhengbing
Rong, Liangce
RESEARCH ON CHEMICAL INTERMEDIATES, 2019, 45 (02) : 769 - 788
[3] Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1′,2′:1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions
Ejjoummany, Abdelaziz
Belaroussi, Rabia
El Hakmaoui, Ahmed
Akssira, Mohamed
Guillaumet, Gerald
Buron, Frederic
Routier, Sylvain
MOLECULES, 2018, 23 (11):
[4] The catalyst-free syntheses of pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives by one-pot, three-component reactions
Ezzati, Mahnaz
Khalafy, Jabbar
Marjani, Ahmad Poursattar
Prager, Rolf H.
TETRAHEDRON, 2017, 73 (47) : 6587 - 6596

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