Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl

被引：45

作者：

Nayak, Amit Kumar ^{[1
]}

Pal, Dilipkumar ^{[2
]}

Santra, Kousik ^{[1
]}

机构：

[1] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut, Mayurbhanj 757086, Odisha, India

[2] Guru Ghasidas Vishwavidyalaya, Dept Pharmaceut Sci, Bilaspur 495009, CG, India

来源：

CARBOHYDRATE POLYMERS | 2014年 / 101卷

关键词：

Tamarind seed polysaccharide; Pectin; lonotropic-gelation; Mucoadhesion; Controlled drug release; Metformin HCl; IN-VITRO; DRUG-DELIVERY; FORMULATION OPTIMIZATION; STATISTICAL OPTIMIZATION; NATURAL GUMS; GEL BEADS; RELEASE; MICROSPHERES; SYSTEM; NANOPARTICLES;

D O I：

10.1016/j.carbpol.2013.09.024

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Novel mucoadhesive beads containing metformin HCl made of low methoxy (LM) pectin-tamarind seed polysaccharide (TSP) polymer-blend was developed through ionotropic-gelation technique and optimized using 3(2) factorial design. Effects of LM pectin and TSP amounts on drug encapsulation efficiency (DEE), and cumulative drug release at 10h (R-10h) were analyzed using response surface methodology. The optimized calcium pectinate-TSP beads containing metformin HCl showed DEE of 95.12 +/- 4.26%, R-101, of 46.53 +/- 3.28%, and mean diameter of 1.93 +/- 0.26 mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. These beads were also characterized by SEM and FTIR. The optimized beads also exhibited pH-dependent swelling, good mucoadhesivity with goat intestinal mucosa and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：220 / 230

页数：11

共 55 条

[1] Application of response surface methodology to formulation of ionotropically gelled gum cordia/gellan beads [J].

Ahuja, Munish ;

Yadav, Monika ;

Kumar, Sumit .

CARBOHYDRATE POLYMERS, 2010, 80 (01) :161-167

[2] Drug release from calcium and zinc pectinate beads: Impact of dissolution medium composition [J].

Assifaoui, Ali ;

Chambin, Odile ;

Cayot, Philippe .

CARBOHYDRATE POLYMERS, 2011, 85 (02) :388-393

[3] In vitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon [J].

Atyabi, F ;

Majzoob, S ;

Iman, M ;

Salehi, M ;

Dorkoosh, F .

CARBOHYDRATE POLYMERS, 2005, 61 (01) :39-51

[4]

Avachat AM, 2011, INDIAN J PHARM EDUC, V45, P86

[5] INFLUENCE OF THE SUBSTITUENTS OF THE CARBOXYL GROUPS AND OF THE RHAMNOSE CONTENT ON THE SOLUTION PROPERTIES AND FLEXIBILITY OF PECTINS [J].

AXELOS, MAV ;

THIBAULT, JF .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1991, 13 (02) :77-82

[6]

Barbosa M.A., 2005, ITBM RBM, V26, P212

[7] Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis [J].

Chakraborty, Santanu ;

Khandai, Madhusmruti ;

Sharma, Anuradha ;

Khanam, Nazia ;

Patra, Ch. Niranjan ;

Dinda, Subas Chandra ;

Sen, Kalyan Kumar .

ACTA PHARMACEUTICA, 2010, 60 (03) :255-266

[8] Formulation and Optimization of Zinc-Pectinate Beads for the Controlled Delivery of Resveratrol [J].

Das, Surajit ;

Ng, Ka-Yun ;

Ho, Paul C. .

AAPS PHARMSCITECH, 2010, 11 (02) :729-742

[9]

Desai KGH, 2005, AAPS PHARMSCITECH, V6

[10]

Deveswaran R., 2009, INT J PHARMTECH RES, V1, P191

← 1 2 3 4 5 6 →