Natural Products Mediated Regulation of Oxidative Stress and DNA Damage in Ultraviolet Exposed Skin Cells

被引：14

作者：

Farooqi, Ammad A. ^{[1
]}

Li, Ruei-Nian ^{[2
]}

Huang, Hurng-Wern ^{[3
]}

Ismail, Muhammad ^{[1
]}

Yuan, Shyng-Shiou F. ^{[4
,5
]}

Wang, Hui-Min D. ^{[6
,7
,8
]}

Liu, Jing-Ru ^{[2
]}

Tang, Jen-Yang ^{[9
,10
,11
]}

Chang, Hsueh-Wei ^{[2
,5
,12
,13
]}

机构：

[1] KRL Hosp, IBGE, Islamabad, Pakistan

[2] Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, Kaohsiung, Taiwan

[3] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 80424, Taiwan

[4] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Translat Res Ctr, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Dept Fragrance & Cosmet Sci, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan

[8] Kaohsiung Med Univ, Ctr Stem Cell, Kaohsiung, Taiwan

[9] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Radiat Oncol, Kaohsiung, Taiwan

[10] Kaohsiung Med Univ Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan

[11] Kaohsiung Municipal Tatung Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan

[12] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung 80424, Taiwan

[13] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2015年 / 16卷 / 12期

关键词：

Natural products; UV; oxidative stress; DNA damage; DNA repair; protection; miRNA; MICRORNA EXPRESSION; DERMAL FIBROBLASTS; EXTRACT PROTECTS; CANCER-CELLS; HACAT CELLS; IN-VITRO; UVB; REPAIR; KERATINOCYTES; E2F1;

D O I：

10.2174/1389201016666150731111308

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV radiations that can alter its structure and function. Substantial fraction of information has been added into the existing pool of knowledge related to natural products mediated biological effects in UV exposed skin cells. Accumulating evidence has started to shed light on the potential of these bioactive ingredients as protective natural products in cosmetics against UV photodamage by exerting biological effects mainly through wide ranging intracellular signalling cascades of oxidative stress and modulation of miRNAs. In this review, we have summarized recently emerging scientific evidences addressing underlying mechanisms of UV induced oxidative stress and deregulation of signalling cascades and how natural products can be used tactfully to protect against UV induced harmful effects.

引用

页码：1078 / 1084

页数：7