Characterization of genes encoding topoisomerase IV of Mycoplasma genitalium

被引：8
作者：
Bailey, CC
Younkins, R
Huang, WM
Bott, KF
机构：
[1] UNIV N CAROLINA,SCH MED,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27599
[2] UNIV N CAROLINA,CURRICULUM GENET,CHAPEL HILL,NC 27599
[3] UNIV UTAH,DEPT ONCOL SCI,DIV MOLEC BIOL & GENET,SALT LAKE CITY,UT 84132
来源：
GENE | 1996年 / 168卷 / 01期
关键词：
cell division; cloning; DNA gyrase; genome partitioning; Mollicutes;
D O I：
10.1016/0378-1119(95)00718-0
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A type-II topoisomerase (Topo-IV) encoded by the parC and parE genes in Escherichia coli and Salmonella typhimurium is thought to be involved in cell septation and in the decatenation of newly replicated chromosomes. We have identified parC and parE homologs in the pleomorphic, wall-less organism Mycoplasma genitalium. Since the mechanics of cell septation in conventional eubacterial species is believed to be mediated by cell-wall constituents, there is no clear understanding of what coordinates that process in wall-less species. The presence of par genes in this bacterium, which has the smallest genome of any free-living organism, suggests that Topo-IV has been evolutionarily conserved because of an essential role in mediating cell division.
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收藏
页码：77 / 80
页数：4
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