Hypoxia, mitochondria and cancer

被引：0
|
作者：
Mazure, Nathalie [1 ,2 ,3 ]
Clavel, Stephan [4 ]
机构：
[1] Univ Nice Sophia Antipolis, CNRS UMR7284, Inst Rech Canc & Vieillissement Nice IRCAN, Inserm U1081, Nice, France
[2] Ctr Antoine Lacassagne, Nice, France
[3] CNRS, MicroNit, Grp Rech 3697, Nice, France
[4] Univ Nice Sophia Antipolis, Ctr Mediterraneen Med Mol, Equipe Physiopathol Cellulaire & Mol Obes & Diabe, Inserm U1065,C3M, Nice, France
来源：
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION | 2016年 / 20卷 / 10期
关键词：
Cancer; HIF; Hypoxia; Mitochondria;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hypoxia plays a predominant role in tumor development and is a sign of poor prognosis for the patient. HIF (Hypoxia-Inducible Factor) is the transcription factor of the cellular response to hypoxia. Mitochondrion is an essential actor in resistance to apoptosis in cancer cells. Mitochondrion participates actively in the metabolic reprogramming of tumor cells. Its physiology probably plays an important role in many cancer processes, A better understanding of these mechanisms is an important future issue in oncology.
引用
收藏
页码：294 / 298
页数：5
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