Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia

被引:27
|
作者
Hirvonen, J
van Erp, TGM
Huttunen, J
Någren, K
Huttunen, M
Aalto, S
Lönnqvist, J
Kaprio, J
Cannon, TD
Hietala, J
机构
[1] Univ Turku, Dept Psychiat, FIN-20520 Turku, Finland
[2] Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland
[3] Univ Turku, Turku PET Ctr, Turku 20521, Finland
[4] Univ Turku, Cent Hosp, Turku 20521, Finland
[5] Univ Calif Los Angeles, Sch Med, Dept Psychol, Los Angeles, CA 90095 USA
[6] Univ Calif Los Angeles, Sch Med, Dept Psychiat, Los Angeles, CA 90095 USA
[7] Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
[8] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, SF-00300 Helsinki, Finland
[9] Abo Akad Univ, Dept Psychol, SF-20500 Turku, Finland
[10] Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland
关键词
dopamine receptors; schizophrenia; positron emission tomography; genetics; twins;
D O I
10.1016/j.pscychresns.2005.10.004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The dopamine hypothesis of schizophrenia postulates that a dysfunctional dopaminergic system is a major pathophysiological mechanism in the disease. Most studies have focused on striatal dopamine D2 receptors, but a disturbed link between dopamine D I and D2 receptors has also been proposed. Schizophrenia is highly heritable, and recent evidence suggests that alterations in the dopaminergic system confer susceptibility for schizophrenia instead of being solely related to the to overt expression of the disease. To explore the impact of genetic vulnerability for schizophrenia on the balance of striatal dopamine D1 and D2 receptors, we studied monozygotic (MZ) and dizygotic (DZ) unaffected co-twins from twin pairs discordant for schizophrenia as well as healthy control twins using positron emission tomography (PET). Both [C-11]SCH 23390 and [C-11]raclopride were used to quantitate D1 and D2 receptor binding, respectively, in the same individuals during the same day. The association between D I and D2 receptor binding was analyzed using conventional region of interests as well as voxel-wise D1/D2 ratio maps. The all levels of analyses failed to show any differences in D1/D2 ratio between the unaffected MZ or DZ co-twins and control twins. We noted rostrocaudally declining and dorsoventrally increasing gradients in D1/D2 ratio in the striatum, with no differences between groups in these gradients. In this sample, we did not find evidence for an association between increased genetic risk for schizophrenia and altered D1/D2 receptor balance in the striatum. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:13 / 20
页数:8
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