Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases

被引：17
作者：
Zhou, Zejun [1 ]
Ding, Miao [1 ]
Huang, Lei [2 ]
Gilkeson, Gary [3 ]
Lang, Ren [4 ]
Jiang, Wei [1 ,5 ]
机构：
[1] Med Univ South Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA
[2] 302 Hosp PIA, Treatment & Res Ctr Infect Dis, Beijing 100039, Peoples R China
[3] Med Univ South Carolina, Dept Med, Div Rheumatol, Charleston, SC 29425 USA
[4] Capital Med Univ, Beijing Chaoyang Hosp, Dept Hepatobiliary Surg, Beijing 10020, Chaoyang Qu, Peoples R China
[5] Med Univ South Carolina, Dept Med, Div Infect Dis, Charleston, SC 29425 USA
来源：
CLINICAL IMMUNOLOGY | 2016年 / 173卷
基金：
北京市自然科学基金;
关键词：
Macrophages; Monocytes; Autoimmune disease; Intestine; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INFLAMMATORY-BOWEL-DISEASE; NONOBESE DIABETIC MICE; CENTRAL-NERVOUS-SYSTEM; HUMAN PERIPHERAL-BLOOD; RHEUMATOID-ARTHRITIS; DENDRITIC CELLS; MULTIPLE-SCLEROSIS; INNATE IMMUNITY; CROHNS-DISEASE;
D O I：
10.1016/j.clim.2016.09.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Monocytes are precursors of macrophages and key players during inflammation and pathogen challenge in the periphery, whereas intestinal resident macrophages act as innate effector cells to engulf and clear bacteria, secrete cytokines, and maintain intestinal immunity and homeostasis. However, perturbation of toll-like receptor signaling pathway in intestinal macrophages has been associated with tolerance breakdown in autoimmune diseases. In the present review, we have summarized and discussed the role of toll-like receptor signals in human intestinal macrophages, and the role of human intestinal macrophages in keeping human intestinal immunity, homeostasis, and autoimmune diseases. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：81 / 86
页数：6
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