Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins

被引：84

作者：

Cadwell, Ken ^{[1
,2
]}

Debnath, Jayanta ^{[3
,4
]}

机构：

[1] NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10003 USA

[2] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[4] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94140 USA

来源：

JOURNAL OF CELL BIOLOGY | 2018年 / 217卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CYCLIC GMP-AMP; NF-KAPPA-B; UNCONVENTIONAL SECRETION; I INTERFERON; GENE ATG16L1; RIG-I; INFLAMMASOME ACTIVATION; NONCANONICAL AUTOPHAGY; CONJUGATION SYSTEMS; CELL AUTOPHAGY;

D O I：

10.1083/jcb.201706157

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions. Recent discoveries are revealing that these same ATGs orchestrate processes that are related to, and yet clearly distinct from, classic autophagy. Autophagy-related functions include secretion, trafficking of phagocytosed material, replication and egress of viral particles, and regulation of inflammatory and immune signaling cascades. Here, we define common processes dependent on ATGs, and discuss the challenges in mechanistically separating autophagy from these related pathways. Elucidating the molecular events that distinguish how individual ATGs function promises to improve our understanding of the origin of diseases ranging from autoimmunity to cancer.

引用

页码：813 / 822

页数：10

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