New methodological approaches for assessing thrombus formation in cardiovascular disease

被引：3

作者：

Hosokawa, Kazuya ^{[1
]}

Ohnishi-Wada, Tomoko ^{[1
]}

Nagasato, Tomoka ^{[1
,2
]}

Sameshima-Kaneko, Hisayo ^{[1
]}

Oyamada, Chiaki ^{[1
]}

Dahlen, Jeffrey ^{[3
]}

机构：

[1] Fujimori Kogyo Co Ltd, Res Inst, Yokohama, Kanagawa, Japan

[2] Grad Sch Med & Dent Sci, Dept Syst Biol Thromboregulat, Kagoshima, Japan

[3] Hikari Dx, San Diego, CA USA

来源：

KARDIOLOGIA POLSKA | 2020年 / 78卷 / 7-8期

关键词：

anticoagulant therapy; antiplatelet therapy; AR chip; PL chip; Total Thrombus-Formation Analysis System; PLATELET-FUNCTION ANALYZER; ACUTE CORONARY SYNDROMES; FLOW-CHAMBER SYSTEM; WARFARIN; THROMBOGENICITY; RIVAROXABAN; CLOPIDOGREL; ASPIRIN; DABIGATRAN; APIXABAN;

D O I：

10.33963/KP.15493

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiplatelet therapy is the mainstay preventive strategy for cardiovascular diseases, and dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor is the standard treatment for patients who underwent percutaneous coronary intervention. The Total Thrombus-Formation Analysis System (T-TAS) is a microchip flow-chamber system developed to evaluate overall thrombus formation under flow conditions, which is reportedly able to assess single and combined antithrombotic therapy. Here, we focus on this new system, T-TAS, and review its characteristics together with those of the conventional systems available for evaluation of antithrombotic therapies for cardiovascular diseases.

引用

页码：667 / 673

页数：7

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