Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila

被引：48
作者：
Alekseyenko, Artyom A. [1 ,2 ]
Ellison, Christopher E. [3 ]
Gorchakov, Andrey A. [1 ,2 ,4 ]
Zhou, Qi [3 ]
Kaiser, Vera B. [3 ]
Toda, Nick [3 ]
Walton, Zaak [3 ]
Peng, Shouyong [1 ]
Park, Peter J. [1 ,5 ]
Bachtrog, Doris [3 ]
Kuroda, Mitzi I. [1 ,2 ]
机构：
[1] Brigham & Womens Hosp, Dept Genet, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[3] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA
[4] Inst Mol & Cell Biol, Novosibirsk 630090, Russia
[5] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA 02115 USA
来源：
GENES & DEVELOPMENT | 2013年 / 27卷 / 08期
关键词：
dosage compensation; MSL complex; Drosophila; chromatin; MSL COMPLEX; X-CHROMOSOME; POSITIVE SELECTION; LETHAL COMPLEX; Y-CHROMOSOME; GENES; EVOLUTION; TRANSCRIPTION; RECRUITMENT; ADAPTATION;
D O I：
10.1101/gad.215426.113
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dosage compensation has arisen in response to the evolution of distinct male (XY) and female (XX) karyotypes. In Drosophila melanogaster, the MSL complex increases male X transcription approximately twofold. X-specific targeting is thought to occur through sequence-dependent binding to chromatin entry sites (CESs), followed by spreading in cis to active genes. We tested this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage compensation. We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation.
引用
收藏
页码：853 / 858
页数：6
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