Prognostic analysis of gastric mucosal dysplasia after endoscopic resection: A single-center retrospective study

Purpose: To analyze the prognostic factors of gastric mucosal dysplasia after endoscopic resection. Methods: 362 patients with gastric mucosal dysplasia diagnosed by endoscopic biopsy and undergoing endoscopic resection from March 2012 to March 2016 were enrolled. Follow-up was longer than 30 months. Basic characteristics of enrolled patients were recorded, including age, gender, surgical procedures, lesion location, pathological type, lesion size, Helicobacter pylori (HP) infection, operation time and wound area. The relationship between the above factors and postoperative residual lesions and recurrence after endoscopic resection of gastric mucosal dysplasia was analyzed. Results: Included were 200 males and 162 females, aged 28-78 years, (mean 59.3 +/- 11.5). Operation time and wound area were not correlated with postoperative recurrence of gastric mucosal dysplasia resected by endoscopic mucosal resection (EMR) (p>0.05). Operation time in patients undergoing endoscopic submucosal dissection (ESD) was longer compared with those of controls (p=0.032). Additionally, wound area was smaller in patients with postoperative residual disease (p=0.003) and postoperative recurrence (p=0.048) after ESD compared with controls. Intestinal metaplasia was a common risk factor for postoperative residual disease and postoperative recurrence of gastric mucosal dysplasia. Lesion location and complete resection were independent risk factors for postoperative recurrence of gastric mucosal dysplasia. Also, pathological findings and HP infection were independent risk factors for recurrence of gastric mucosal dysplasia after endoscopic resection. Conclusions: In patients undergoing ESD of gastric mucosal dysplasia, prolonged operation time may increase the possibility of postoperative residual disease. Complete resection may reduce the possibility for recurrence. Intestinal metaplasia may serve as a common independent risk factor for postoperative residual disease and recurrence of gastric mucosal dysplasia after endoscopic resection.