Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) in bipolar II disorder, but only to ALDH2 in bipolar I disorder, in Han Chinese

被引：9

作者：

Chang, Yun-Hsuan ^{[1
,2
,3
]}

Lee, Sheng-Yu ^{[4
,5
]}

Wang, Tzu-Yun ^{[2
,4
]}

Chen, Shiou-Lan ^{[6
]}

Tzeng, Nian-Sheng ^{[7
]}

Chen, Po See ^{[2
,4
,8
]}

Lee, I. Hui ^{[2
,4
,9
]}

Chen, Kao Chin ^{[2
,4
]}

Huang, San-Yuan ^{[7
]}

Yang, Yen Kuang ^{[2
,4
,8
,10
]}

Ko, Hui-Chen ^{[1
,3
,10
]}

Lu, Ru-Band ^{[1
,2
,4
,8
,9
,10
]}

机构：

[1] Natl Cheng Kung Univ, Inst Allied Hlth Sci, Div Clin Psychol, Tainan 70428, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Psychiat, Tainan 70428, Taiwan

[3] Asia Univ, Dept Psychol, Taichung, Taiwan

[4] Natl Cheng Kung Univ Hosp, Dept Psychiat, Tainan 70428, Taiwan

[5] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Coll Med, Dept Neurol, Kaohsiung, Taiwan

[7] Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Psychiat, Taipei, Taiwan

[8] Natl Cheng Kung Univ, Coll Med, Addict Res Ctr, Tainan 70101, Taiwan

[9] Natl Hlth Res Inst, Ctr Neuropsychiatr Res, Zhunan, Miaoli County, Taiwan

[10] Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan 70101, Taiwan

来源：

BIPOLAR DISORDERS | 2015年 / 17卷 / 05期

关键词：

ADH1B*2; alcohol dependence; ALDH2; bipolar disorder; comorbidity; Han Chinese; SUBSTANCE USE DISORDERS; PSYCHIATRIC-DISORDERS; AXIS-I; ABUSE; GENOTYPES; METABOLISM; DOPAMINE; GENES; RISK; POLYMORPHISMS;

D O I：

10.1111/bdi.12313

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

ObjectivesA high prevalence rate of bipolar disorder (BP) comorbid with alcohol dependence (AD) (BP+AD) in Western patients with BP has been reported, but whether this is true for Han Chinese with BP is uncertain. We explored the prevalence of BP+AD in a Han Chinese population with BP, and investigated the effect of alcohol-metabolizing genotypes on bipolar I disorder (BP-I) + AD and bipolar II disorder (BP-II) + AD. MethodsHealthy controls (HCs) (n=672) and 18- to 65-year-old patients with BP (BP-I: n=530; BP-II: n=788) were recruited. Patients with any other major or minor mental illnesses, neurological disorders, or organic mental disorders were excluded. A polymerase chain reaction and restriction fragment length polymorphism analysis was used to determine genotypes for alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2), two alcohol-metabolizing enzymes. ResultsAD comorbidity rates were 11.7% with BP-I and 17.1% with BP-II. Significantly fewer patients with BP not comorbid with AD (BP-AD) carried the AHD1B*1 allele than did the HCs. Logistic regression analysis showed a main effect of ALDH2*1/*1 only in the BP-I-AD group. In BP+AD patients, logistic regression analysis showed main effects of ALDH2*1/*1 and ADH1B*1/*1 only in the BP-II+AD group. ConclusionsHaving BP-II+AD may be related to ALDH2 and ADH1B, but having BP-I+AD may be related only to ALDH2. We conclude that ALDH2 and ADH1B have different effects in Han Chinese patients with BP-I+AD and BP-II+AD.

引用

页码：536 / 542

页数：7

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[1] Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum:: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethahol treated rats [J].