LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

被引：28
作者：
Ali, Mohammad [1 ]
Saroha, Ashish [1 ]
Pewzner-Jung, Yael [1 ]
Futerman, Anthony H. [1 ]
机构：
[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel
来源：
FEBS LETTERS | 2015年 / 589卷 / 17期
基金：
以色列科学基金会;
关键词：
Ceramide; Sphingolipid; Ceramide synthase 2; LPS-mediated sepsis; Tumor necrosis factor alpha converting enzyme; Tumor necrosis factor alpha; NECROSIS-FACTOR-ALPHA; ABLATION; INFLAMMATION; FAILURE;
D O I：
10.1016/j.febslet.2015.06.045
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor necrosis factor alpha (TNF alpha) is an inflammatory cytokine that plays an intimate role in septic shock. Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30 h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very-long acyl chain ceramides, die within similar to 10 h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNF alpha secretion as a result of enhanced activity of TNF alpha-converting enzyme (TACE). We discuss the relationship between the sphingolipid acyl chain length and TACE activity and the relevance of this data to septic shock. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2213 / 2217
页数：5
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