Rash, Hepatotoxicity and Hyperbilirubinemia Among Kenyan Infants Born to HIV-infected Women Receiving Triple-antiretroviral Drugs for the Prevention of Mother-to-child HIV Transmission

被引：4
作者：
Minniear, Timothy D. [1 ,2 ]
Zeh, Clement [2 ,3 ]
Polle, Nicholas [4 ]
Masaba, Rose [3 ]
Peters, Philip J. [2 ]
Oyaro, Boaz [3 ]
Akoth, Benta [3 ]
Ndivo, Richard [3 ]
Angira, Frank [3 ]
Mills, Lisa A. [2 ,3 ]
Thomas, Timothy K. [2 ,3 ]
机构：
[1] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA
[2] CDC, Div HIV AIDS Prevent, Atlanta, GA 30333 USA
[3] Kenya Med Res Inst CDC Res & Publ Hlth Collaborat, Kisumu, Kenya
[4] Minist Hlth Kenya, Nairobi, Kenya
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2012年 / 31卷 / 11期
关键词：
HIV; antiretroviral agents; toxicity; infant; newborn; BREAST-MILK;
D O I：
10.1097/INF.0b013e318267ef6a
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We compared adverse events among breast-feeding neonates born to Kenyan mothers receiving triple-antiretroviral therapy, including either nevirapine or nelfinavir. Nevirapine-exposed infants had an absolute increase in the risk of rash but no significant risk differences for hepatotoxicity or high-risk hyperbilirubinemia compared with nelfinavir-exposed infants. From an infant-safety perspective, nevirapine-based regimens given during pregnancy and breast-feeding are viable options where alternatives to breast milk are not safe, affordable or feasible.
引用
收藏
页码：1155 / 1157
页数：3
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