Rash, Hepatotoxicity and Hyperbilirubinemia Among Kenyan Infants Born to HIV-infected Women Receiving Triple-antiretroviral Drugs for the Prevention of Mother-to-child HIV Transmission

被引：4
|
作者：
Minniear, Timothy D. [1 ,2 ]
Zeh, Clement [2 ,3 ]
Polle, Nicholas [4 ]
Masaba, Rose [3 ]
Peters, Philip J. [2 ]
Oyaro, Boaz [3 ]
Akoth, Benta [3 ]
Ndivo, Richard [3 ]
Angira, Frank [3 ]
Mills, Lisa A. [2 ,3 ]
Thomas, Timothy K. [2 ,3 ]
机构：
[1] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA
[2] CDC, Div HIV AIDS Prevent, Atlanta, GA 30333 USA
[3] Kenya Med Res Inst CDC Res & Publ Hlth Collaborat, Kisumu, Kenya
[4] Minist Hlth Kenya, Nairobi, Kenya
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2012年 / 31卷 / 11期
关键词：
HIV; antiretroviral agents; toxicity; infant; newborn; BREAST-MILK;
D O I：
10.1097/INF.0b013e318267ef6a
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We compared adverse events among breast-feeding neonates born to Kenyan mothers receiving triple-antiretroviral therapy, including either nevirapine or nelfinavir. Nevirapine-exposed infants had an absolute increase in the risk of rash but no significant risk differences for hepatotoxicity or high-risk hyperbilirubinemia compared with nelfinavir-exposed infants. From an infant-safety perspective, nevirapine-based regimens given during pregnancy and breast-feeding are viable options where alternatives to breast milk are not safe, affordable or feasible.
引用
收藏
页码：1155 / 1157
页数：3
相关论文
共 50 条
  • [21] Safety and Efficacy of HIV Hyperimmune Globulin for Prevention of Mother-to-Child HIV Transmission in HIV-1-Infected Pregnant Women and Their Infants in Kampala, Uganda (HIVIGLOB/NVP STUDY)
    Onyango-Makumbi, Carolyne
    Omer, Saad B.
    Mubiru, Michael
    Moulton, Lawrence H.
    Nakabiito, Clemensia
    Musoke, Philippa
    Mmiro, Francis
    Zwerski, Sheryl
    Wigzell, Hans
    Falksveden, Lars
    Wahren, Britta
    Antelman, Gretchen
    Fowler, Mary Glenn
    Guay, Laura
    Jackson, J. Brooks
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 58 (04) : 399 - 407
  • [22] Safety of antiretroviral prophylaxis of perinatal transmission for HIV-infected pregnant women and their infants
    Mofenson, LM
    Munderi, P
    JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2002, 30 (02) : 200 - 215
  • [23] Field effectiveness of combination antiretroviral prophylaxis for the prevention of mother-to-child HIV transmission in rural Zambia
    Gartland, Matthew G.
    Chintu, Namwinga T.
    Li, Michelle S.
    Lembalemba, Mwila K.
    Mulenga, Saziso N.
    Bweupe, Maximillian
    Musonda, Patrick
    Stringer, Elizabeth M.
    Stringer, Jeffrey S. A.
    Chi, Benjamin H.
    AIDS, 2013, 27 (08) : 1253 - 1262
  • [24] High mortality in HIV-infected children diagnosed in hospital underscores need for faster diagnostic turnaround time in prevention of mother-to-child transmission of HIV (PMTCT) programs
    Anjuli Wagner
    Jennifer Slyker
    Agnes Langat
    Irene Inwani
    Judith Adhiambo
    Sarah Benki-Nugent
    Ken Tapia
    Irene Njuguna
    Dalton Wamalwa
    Grace John-Stewart
    BMC Pediatrics, 15
  • [25] High mortality in HIV-infected children diagnosed in hospital underscores need for faster diagnostic turnaround time in prevention of mother-to-child transmission of HIV (PMTCT) programs
    Wagner, Anjuli
    Slyker, Jennifer
    Langat, Agnes
    Inwani, Irene
    Adhiambo, Judith
    Benki-Nugent, Sarah
    Tapia, Ken
    Njuguna, Irene
    Wamalwa, Dalton
    John-Stewart, Grace
    BMC PEDIATRICS, 2015, 15
  • [26] Risk factors for perinatal transmission of HIV among women attending prevention of mother-to-child transmission clinics in Northwest Nigeria
    Sowale, Oluwakemi Yetunde
    Olakunde, Babayemi O.
    Obi, Chinedu
    Itiola, Ademola J.
    Erhunmwunse, Oluwayemisi
    Melvin, Sandra C.
    AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2019, 31 (03): : 326 - 332
  • [27] Preterm delivery risk in women initiating antiretroviral therapy to prevent HIV mother-to-child transmission
    Short, C-E S.
    Douglas, M.
    Smith, J. H.
    Taylor, G. P.
    HIV MEDICINE, 2014, 15 (04) : 233 - 238
  • [28] Factors that promote HIV disclosure among women attending prevention of mother-to-child transmission in a state in South Nigeria
    Subulade, Adetumi A.
    Salami, Taofik A.
    Adewuyi, Gbolagade M.
    HIV & AIDS REVIEW, 2018, 17 (04): : 283 - 287
  • [29] Social concerns related to HIV status disclosure and participation in the prevention of mother-to-child transmission of HIV care among pregnant women in Kenya
    Björn Nordberg
    Erin E. Gabriel
    Edwin Were
    Eunice Kaguiri
    Anna Mia Ekström
    Anna Kågesten
    Susanne Rautiainen
    BMC Pregnancy and Childbirth, 20
  • [30] Social concerns related to HIV status disclosure and participation in the prevention of mother-to-child transmission of HIV care among pregnant women in Kenya
    Nordberg, Bjorn
    Gabriel, Erin E.
    Were, Edwin
    Kaguiri, Eunice
    Ekstrom, Anna Mia
    Kagesten, Anna
    Rautiainen, Susanne
    BMC PREGNANCY AND CHILDBIRTH, 2020, 20 (01)
12345