Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis

被引:97
作者
Ganz, Tomas [1 ]
Nemeth, Elizabeta
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
来源
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2012年 / 2卷 / 05期
关键词
HEPATIC HEPCIDIN EXPRESSION; REGULATED EIF2-ALPHA KINASE; GENOME-WIDE ASSOCIATION; MESSENGER-RNA LEVELS; PEPTIDE HEPCIDIN; GENE-EXPRESSION; ANEMIA; OVERLOAD; SERUM; TMPRSS6;
D O I
10.1101/cshperspect.a011668
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Hemoglobinopathies and other disorders of erythroid cells are often associated with abnormal iron homeostasis. We review the molecular physiology of intracellular and systemic iron regulation, and the interactions between erythropoiesis and iron homeostasis. Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation.
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页数:13
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