Characterizing the effect of heavy metal contamination on marine mussels using metabolomics

被引：74

作者：

Kwon, Yong-Kook ^{[1
,2
]}

Jung, Young-Sang ^{[1
]}

Park, Jong-Chul ^{[1
,2
]}

Seo, Jungju ^{[1
]}

Choi, Man-Sik ^{[2
,3
]}

Hwang, Geum-Sook ^{[1
,2
]}

机构：

[1] Korea Basic Sci Inst, Seoul Ctr, Seoul 136713, South Korea

[2] Chungnam Natl Univ, Grad Sch Analyt Sci & Technol, Taejon 305764, South Korea

[3] Chungnam Natl Univ, Dept Marine Environm Sci, Taejon 305764, South Korea

来源：

MARINE POLLUTION BULLETIN | 2012年 / 64卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Marine mussel; Heavy metal; Contamination; Metabolomics; NMR; Multivariate analysis; NMR-BASED METABOLOMICS; MYTILUS-EDULIS; ENERGY-METABOLISM; AMINO-ACIDS; ANOXIA; GALLOPROVINCIALIS; INVERTEBRATES; PURIFICATION; POLLUTION; RESPONSES;

D O I：

10.1016/j.marpolbul.2012.06.012

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Marine mussels (Mytilus) are widely used as bioindicators to measure pollution in marine environments. In this study, H-1 NMR spectroscopy and multivariate statistical analyses were used to differentiate mussel groups from a heavy metal-polluted area (Onsan Bay) and a clean area (Dokdo area). Principal component analysis and orthogonal projection to latent structure-discriminant analysis revealed significant separation between extracts of mussels from Onsan Bay and from the Dokdo area. Organic osmolytes (betaine and taurine) and free amino acids (alanine, arginine, glutamine, phenylalanine, and threonine) were more highly accumulated in Onsan Bay mussels compared with Dokdo mussels. These results demonstrate that NMR-based metabolomics can be used as an efficient method for characterizing heavy metal contamination derived from polluted area compared to clean area and to identify metabolites related to environments that are contaminated with heavy metals. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1874 / 1879

页数：6

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